Helmbold Alan F, Slim Jennifer N, Morgan Jennifer, Castillo-Rojas Laudino M, Shry Eric A, Slim Ahmad M
Brooke Army Medical Center, MCHE MDC Cardiology Service, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234-6200, USA.
Cholesterol. 2010;2010:306147. doi: 10.1155/2010/306147. Epub 2010 Feb 24.
Objective. To assess the effectiveness of niacin/fish oil combination therapy in reducing Lipoprotein (a) [Lp(a)] levels after twelve weeks of therapy. Background. Lipoprotein (a) accumulates in atherosclerotic lesions and promotes smooth muscle cell growth and is both atherogenic and thrombogenic. A clinical trials of combination therapy for the reduction of Lp(a) has not been previously reported. Methods. The study was an observational study following subjects with an elevated Lp(a) (>70 nmol/L) to assess impact of 12 weeks of combination Omega 3FA, niacin, and the Mediterranean diet on Lp(a). Results. Twenty three patients were enrolled with 7 patients lost to follow up and 2 patients stopped due to adverse events. The average Lp(a) reduction in the remaining 14 subjects after 12 weeks of combination therapy was 23% ± 17% [P = .003] with a significant association of the reduction of Lp(a) with increasing baseline levels of Lp(a) [R(2) = 0.633, P = .001]. Conclusions. There was a significant reduction in Lp(a) levels with combination therapy. A more pronounced effect was noted in patients with higher baseline levels of Lp(a).
目的。评估烟酸/鱼油联合疗法在治疗12周后降低脂蛋白(a)[Lp(a)]水平的有效性。背景。脂蛋白(a)在动脉粥样硬化病变中蓄积，促进平滑肌细胞生长，具有致动脉粥样硬化和致血栓形成的作用。此前尚未有关于联合疗法降低Lp(a)的临床试验报道。方法。本研究为一项观察性研究，跟踪Lp(a)升高（>70 nmol/L）的受试者，以评估12周的ω-3脂肪酸、烟酸和地中海饮食联合治疗对Lp(a)的影响。结果。共纳入23例患者，7例失访，2例因不良事件停药。联合治疗12周后，其余14名受试者的Lp(a)平均降低23%±17%[P = 0.003]，Lp(a)降低与Lp(a)基线水平升高显著相关[R(2)=0.633，P = 0.001]。结论。联合疗法可使Lp(a)水平显著降低。在Lp(a)基线水平较高的患者中观察到更明显的效果。
