Department of Radiology, Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Mol Imaging Biol. 2012 Apr;14(2):245-51. doi: 10.1007/s11307-011-0488-0.
To investigate the utility of (11)C-acetate positron emission tomography/computed tomography (PET/CT) for staging of bladder cancer and response assessment after neoadjuvant chemotherapy.
Seventeen patients underwent (11)C-acetate PET/CT ≤1 month before radical cystectomy (RC) and pelvic lymph node dissection (PLND). Ten patients had undergone neoadjuvant chemotherapy prior to PET. Histopathology from RC and PLND (n = 16) or nodal biopsy (n = 1) served as gold standard.
Eight of 10 residual tumors showed abnormal (11)C-acetate uptake; two cases of residual TiS were false negative, three cases were false positive, and three true negative. Three patients showed true positive uptake in LN. False positive uptake occurred in 14 LN regions secondary to granulomatous disease after prior intravesical Bacillus Calmette-Guerin (BCG) therapy.
(11)C-acetate has good sensitivity for bladder cancer and LN metastases. However, false positive uptake due to inflammation or granulomatous infection can occur, limiting the staging utility of (11)C-acetate after prior intravesical BCG therapy.
研究 11C-乙酸正电子发射断层扫描/计算机断层扫描（PET/CT）在膀胱癌分期和新辅助化疗后反应评估中的应用。
17 例患者在根治性膀胱切除术（RC）和盆腔淋巴结清扫术（PLND）前 1 个月内接受 11C-乙酸 PET/CT。10 例患者在 PET 前接受了新辅助化疗。RC 和 PLND（n=16）或淋巴结活检（n=1）的组织病理学为金标准。
10 例残留肿瘤中有 8 例显示异常 11C-乙酸摄取；2 例 TiS 残留假阴性，3 例假阳性，3 例真阴性。3 例患者在 LN 中显示真正的阳性摄取。假阳性摄取发生在 14 个 LN 区域，这是由于先前膀胱内卡介苗（BCG）治疗后的肉芽肿病。
11C-乙酸对膀胱癌和 LN 转移具有良好的敏感性。然而，由于炎症或肉芽肿感染引起的假阳性摄取可能会发生，限制了 11C-乙酸在先前膀胱内 BCG 治疗后的分期应用。
