Sandblom Gabriel, Sörensen Jens, Lundin Niclas, Häggman Michael, Malmström Per-Uno
Department of Surgery, Uppsala University Hospital, Uppsala, Sweden.
Urology. 2006 May;67(5):996-1000. doi: 10.1016/j.urology.2005.11.044.
To evaluate positron emission tomography with C11-acetate as a method for detecting and localizing prostate cancer recurrence. No technique for localizing and detecting prostate cancer recurrence after biochemical relapse available today is sensitive enough to localize recurrence at a stage at which salvage radiotherapy is still curative.
Twenty patients (age 56 to 77 years) who had undergone radical prostatectomy and had an increasing prostate-specific antigen level measured on two consecutive occasions were included. In addition to the investigations usually performed when prostate cancer recurrence is suspected, they underwent positron emission tomography with C11-acetate as the marker.
Pathologic uptake of acetate was seen in 15 (75%) of the 20 patients. In 8 of these patients, a solitary lesion was found (seven in the prostatic fossa and one at the regional lymph nodes). Multiple lesions were found in the remaining 7. False-positive uptake was seen in 3 men (15%). Additional investigations in these men revealed pathologic findings other than prostate cancer.
Positron emission tomography with C11-acetate as marker is a promising method for early detection and localization of prostate cancer recurrence. False-positive uptake does occur.
评估以C11 - 醋酸盐为标记物的正电子发射断层扫描作为检测和定位前列腺癌复发的方法。目前尚无足够灵敏的技术可在生化复发后定位和检测前列腺癌复发，从而在挽救性放疗仍可治愈的阶段定位复发部位。
纳入20例（年龄56至77岁）接受过前列腺根治术且连续两次测得前列腺特异性抗原水平升高的患者。除了怀疑前列腺癌复发时通常进行的检查外，他们还接受了以C11 - 醋酸盐为标记物的正电子发射断层扫描。
20例患者中有15例（75%）出现醋酸盐的病理性摄取。其中8例患者发现单个病灶（7例位于前列腺窝，1例位于区域淋巴结）。其余7例发现多个病灶。3名男性（15%）出现假阳性摄取。对这些男性进行的进一步检查发现了前列腺癌以外的病理结果。
以C11 - 醋酸盐为标记物的正电子发射断层扫描是早期检测和定位前列腺癌复发的一种有前景的方法。确实会出现假阳性摄取。
