鸡脾脏细胞产生抗体的抑制性T细胞的特性。I. 抗原诱导的抑制性细胞是CT8+、TcR1+（γδ）T细胞。
Characterization of suppressor T cells for antibody production by chicken spleen cells. I. Antigen-induced suppressor cells are CT8+, TcR1+ (gamma delta) T cells.
作者信息
Quere P, Cooper M D, Thorbecke G J
机构信息
Institut National de la Recherche Agronomique, Monnaie, France.
出版信息
Immunology. 1990 Dec;71(4):517-22.
Abstract
Suppressor activity of chicken T cells has been previously defined in an in vitro assay of the secondary response of spleen cells to sheep erythrocytes. We have used this assay to examine the phenotype of the T-cell subpopulation(s) that is responsible for this activity. The suppressive effect was alleviated by removal of the TcR1+ (gamma delta) and CD8+ subpopulations, but was unaffected by the removal of the TcR2+ (alpha beta) and CD4+ cells. The addition of a histamine type 2 (H2) receptor antagonist, cimetidine, enhanced the antibody response in the presence of the suppressor cells. The data indicate that one type of T cells with suppressor capability expresses TcR1 and the CD8 accessory molecule, and that these cells may be influenced via H2 receptors.
摘要
鸡T细胞的抑制活性先前已在脾细胞对绵羊红细胞二次反应的体外试验中得到定义。我们已利用该试验来检测负责此活性的T细胞亚群的表型。通过去除TcR1 +（γδ）和CD8 +亚群可减轻抑制作用，但去除TcR2 +（αβ）和CD4 +细胞对其无影响。添加组胺2型（H2）受体拮抗剂西咪替丁，在存在抑制细胞的情况下增强了抗体反应。数据表明，一种具有抑制能力的T细胞表达TcR1和CD8辅助分子，并且这些细胞可能通过H2受体受到影响。
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本文引用的文献
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