人结肠上皮内淋巴细胞是抑制细胞。
Human colonic intra-epithelial lymphocytes are suppressor cells.
作者信息
Hoang P, Dalton H R, Jewell D P
机构信息
Gastroenterology Unit, Radcliffe Infirmary, Oxford, England, UK.
出版信息
Clin Exp Immunol. 1991 Sep;85(3):498-503. doi: 10.1111/j.1365-2249.1991.tb05756.x.
Abstract
Human colonic intra-epithelial lymphocytes (IEL) suppress the proliferation of autologous lamina propria lymphocytes, but not autologous peripheral blood mononuclear cells, when stimulated with phytohaemagglutinin. This suppressor function is mediated by a CD8-dependent soluble factor and is not related to the expression of the gamma delta T cell receptor. These findings may be relevant to the induction of mucosal tolerance. However, there is no defect in suppressor activity of colonic IEL in inflammatory bowel disease.
摘要
人结肠上皮内淋巴细胞（IEL）在用植物血凝素刺激时，可抑制自体固有层淋巴细胞的增殖，但不抑制自体外周血单个核细胞的增殖。这种抑制功能由一种依赖CD8的可溶性因子介导，且与γδT细胞受体的表达无关。这些发现可能与黏膜耐受性的诱导有关。然而，炎症性肠病患者结肠IEL的抑制活性并无缺陷。
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