Department of Psychology, Brock University, St. Catharines, Ontario, Canada.
Behav Sleep Med. 2011;9(2):68-85. doi: 10.1080/15402002.2011.557989.
Event-related potentials may be applied to directly measure information-processing deficits associated with the problem of insomnia. This study is a systematic investigation of cortical hyperarousal during the sleep-onset period in participants with sleep-onset insomnia complaints. Thirteen poor sleepers and twelve good sleepers (GS) were administered an oddball task while awake in the morning and evening and during repeated sleep-onset attempts. Participants signaled detection of a higher pitch target tone as they fell asleep. P2 amplitude was significantly smaller for poor sleepers compared to GS, following standard stimuli at all fronto-central sites, in the pre-sleep waking period at sleep onset. Groups did not differ for N1, N350, or P300 in wake, Stage 1, or Stage 2. The smaller P2 indicates that poor sleepers failed to inhibit the irrelevant standard stimuli. This hyper-attentiveness may explain chronic problems with sleep initiation and could be the target of behavioral and pharmaceutical treatment strategies.
事件相关电位可用于直接测量与失眠问题相关的信息处理缺陷。本研究系统地调查了睡眠起始期失眠抱怨者在睡眠起始期的皮层过度唤醒。13 名睡眠质量差的人和 12 名睡眠质量好的人（GS）在早晨和晚上清醒时以及多次尝试入睡时接受了一项分差任务。当参与者入睡时，他们会发出检测到高音目标音的信号。与 GS 相比，在睡眠起始前的清醒期，所有额中央部位的标准刺激后，差睡眠者的 P2 振幅明显较小。组间在清醒、N1、N350 或 Stage 1 和 Stage 2 时的 P300 没有差异。较小的 P2 表明，差睡眠者未能抑制不相关的标准刺激。这种过度关注可能解释了慢性睡眠起始问题，并且可能成为行为和药物治疗策略的目标。
