Department of Psychiatry, Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Pharmacopsychiatry. 2011 May;44(3):114-8. doi: 10.1055/s-0031-1275658. Epub 2011 Apr 13.
The aim of this study was to survey the use of anticholinergic medication (ACM) in Asia between 2001 and 2009 and examine its demographic and clinical correlates.
A total of 6 761 hospitalized schizophrenia patients in 9 Asian countries and territories were examined between 2001 and 2009. The patients' socio-demographic and clinical characteristics and the prescriptions of psychotropic drugs were recorded using a standardized protocol and data collection procedure.
The frequency of ACM prescription decreased from 66.3% in 2001, to 52.8% in 2004 and 54.6% in 2009, with wide inter-country variations at each time period. Multiple logistic regression analysis of the whole sample showed that patients taking ACM presented with more severe positive, negative, and extrapyramidal symptoms. They were also more likely to receive first-generation and depot antipsychotics and antipsychotic polypharmacy, and less likely to receive second-generation ones.
The wide variation in ACM prescription across Asia suggests that a combination of clinical, social, economic and cultural factors play a role in determining the use of these drugs. Regular reviews of ACM use are desirable to reveal the discrepancy between treatment guidelines and clinical practice.
本研究旨在调查 2001 年至 2009 年间亚洲地区抗胆碱能药物（ACM）的使用情况，并探讨其与人口统计学和临床相关因素的关系。
2001 年至 2009 年间，对来自 9 个亚洲国家和地区的 6761 名住院精神分裂症患者进行了检查。使用标准化协议和数据收集程序记录了患者的社会人口统计学和临床特征以及精神药物的处方情况。
ACM 的处方频率从 2001 年的 66.3%下降到 2004 年的 52.8%和 2009 年的 54.6%，每个时期的国家间差异都很大。对全样本进行的多变量逻辑回归分析显示，服用 ACM 的患者表现出更严重的阳性、阴性和锥体外系症状。他们更有可能接受第一代和长效抗精神病药以及抗精神病药联合治疗，而不太可能接受第二代药物。
亚洲各地 ACM 处方的广泛差异表明，临床、社会、经济和文化因素的综合作用决定了这些药物的使用。定期审查 ACM 的使用情况是必要的，以揭示治疗指南与临床实践之间的差异。
