[Parathyroïd adenoma induced by long term lithium therapy: case report and review].
作者信息
Coulet O, Achache M, Derkenne R, Javelle E, Le Bougeant P, Molinier S, Tomasi M
机构信息
Hôpital d'Instruction des Armées Laveran, Service ORL et chirurgie cervico-faciale, 13000 Marseille, France.
出版信息
Rev Laryngol Otol Rhinol (Bord). 2010;131(3):213-6.
UNLABELLED
We report a case of a parathyroid adenoma during a long term lithium treatment without therapeutic overdose.
CASE REPORT
A 73-years-old woman presented a demonstrative biological syndrome with hypercalcemia, elevated parathormone, normal urinary cyclic AMP, normocalciuria.
CONCLUSION
This lithium induced hyperparathyroidism differs from the classic primary hyperparathyroidism with parthyroid adenoma where urinary cyclic AMP excretion is elevated and where there is hypercalciuria. Lithium is blocking the negative feedback of calcium on parathormone secretion and stimulates the growth of parathyroid adenoma. Treatment is surgical and consists in adenoma ablation. Calcemia follow up is indicated in patients with long term lithium therapy
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