Zhi J G, Nightingale C H
Department of Pharmacy Services, Hartford Hospital, CT 06115.
Pol J Pharmacol Pharm. 1990 Jan-Feb;42(1):43-8.
When the experimental error of concentration-time data is represented by the relative error model (i.e. constant coefficient of variation) two approaches (direct input of concentration-time data with 1/C2i as a weighting factor, and input of logarithmically transformed concentration-time data) are equally effective in pharmacokinetic modelling. Advantages of the latter approach are discussed.
当浓度-时间数据的实验误差由相对误差模型表示（即变异系数恒定）时，两种方法（以1/C2i作为加权因子直接输入浓度-时间数据，以及输入对数转换后的浓度-时间数据）在药代动力学建模中同样有效。文中讨论了后一种方法的优点。
