Department of Chemistry, The University of Western Ontario, 1151 Richmond Street, London, Canada N6A5B7.
ACS Appl Mater Interfaces. 2011 May;3(5):1740-8. doi: 10.1021/am200241b. Epub 2011 Apr 26.
The functionalization of surfaces with poly(ethylene oxide) (PEO) is an effective means of imparting resistance to the adsorption of proteins and the attachment and growth of cells, properties that are critical for many biomedical applications. In this work, a new hyperthermal hydrogen induced cross-linking (HHIC) method was explored as a simple one-step approach for attaching PEO to surfaces through the selective cleavage of C-H bonds and subsequent cross-linking of the resulting carbon radicals. In order to study the effects of the process on the polymer, PEO-coated silicon wafers were prepared and the effects of different treatment times were investigated. Subsequently, using an optimized treatment time and a modified butyl polymer with increased affinity for PEO, the technique was applied to butyl rubber surfaces. All of the treated surfaces exhibited significantly reduced protein adsorption and cell growth relative to control surfaces and compared favorably with surfaces that were functionalized with PEO using conventional chemical methods. Thus HHIC is a simple and effective means of attaching PEO to non-functional polymer surfaces.
通过聚环氧乙烷（PEO）对表面进行功能化是赋予其抵抗蛋白质吸附、细胞附着和生长特性的有效手段，这些特性对于许多生物医学应用至关重要。在这项工作中，探索了一种新的超热氢诱导交联（HHIC）方法，作为通过选择性地裂解 C-H 键并随后交联所得的碳自由基将 PEO 附着到表面的简单一步法。为了研究该过程对聚合物的影响，制备了涂有 PEO 的硅片，并研究了不同处理时间的影响。随后，使用优化的处理时间和对 PEO 具有更高亲和力的改性丁基聚合物，将该技术应用于丁基橡胶表面。与对照表面相比，所有处理过的表面的蛋白质吸附和细胞生长均显著降低，并且与使用常规化学方法官能化的 PEO 的表面相比具有优势。因此，HHIC 是将 PEO 附着到非功能聚合物表面的简单有效方法。
