Division of Andrology, Mansoura , Egypt.
Expert Opin Ther Targets. 2011 Aug;15(8):913-29. doi: 10.1517/14728222.2011.577419. Epub 2011 Apr 14.
Peyronie's disease (PD) is an acquired benign connective tissue disorder of the penis, characterized by the development of fibrotic plaques, that can cause different degrees of bending, narrowing or shortening. Medical treatment for PD remains a major challenge. Impressive progress in our understanding of the molecular mechanisms of PD pathogenesis has uncovered several promising molecular targets for antifibrotic treatments.
This review covers the literature pertaining to the exploration of therapeutic targets for PD. The search included: i) a MEDLINE search from 1941 to January 2011, limited to English-language medical literature, ii) relevant abstracts from 2009 and 2010, iii) relevant textbooks and iv) a pipeline search for therapeutics in development.
Rapid translational research depends on our ability to develop rational therapies targeted to penile tunical fibrosis, which necessitate a sound knowledge of the biology, biochemistry and the physiological role of fibroblasts, myofibroblasts and stem cells in PD. Much remains to be learned about the pathogenesis of PD. Although there are many interesting therapeutic targets, we are confronted with some questions when identifying new targets, or when validating potential therapeutic options.
佩罗尼氏病（PD）是一种获得性阴茎良性结缔组织疾病，其特征为纤维斑块的形成，可导致不同程度的弯曲、变窄或缩短。PD 的医学治疗仍然是一个主要挑战。对 PD 发病机制的分子机制的理解取得了令人瞩目的进展，为抗纤维化治疗揭示了几个有前途的分子靶点。
这篇综述涵盖了 PD 治疗靶点探索的文献。搜索包括：i）从 1941 年到 2011 年 1 月的 MEDLINE 搜索，仅限于英文医学文献，ii）2009 年和 2010 年的相关摘要，iii）相关教科书和 iv）正在开发的治疗药物的流水线搜索。
快速转化研究取决于我们开发针对阴茎白膜纤维化的合理疗法的能力，这需要对纤维化、肌成纤维细胞和干细胞在 PD 中的生物学、生物化学和生理作用有一个正确的认识。PD 的发病机制仍有许多需要了解的地方。虽然有许多有趣的治疗靶点，但在确定新靶点或验证潜在的治疗选择时，我们面临着一些问题。
