Zhang Li-Chun, Zhang Tian-Yu, Dai Pei-dong, Luo Jian-feng
Department of Otorhinolaryngology, Shanghai Medical College, Fudan University, China.
Acta Otolaryngol. 2011 Jul;131(7):708-15. doi: 10.3109/00016489.2011.556662. Epub 2011 Apr 15.
The papers collected in our study demonstrated that there were no significant differences in the effectiveness of sound transmission and stability of the prosthesis between the titanium and non-titanium group. However, further randomized controlled trials with large sample sizes are needed to improve the estimation.
To compare the effectiveness of sound transmission and stability of the prostheses in the titanium or non-titanium ossiculoplasty groups by meta-analysis for clinical implications and applications.
Previous studies comparing the hearing status of patients with titanium and non-titanium prostheses were reviewed on PubMed, accompanied by a manual search of all the related references. The eligibility of the investigation was independently confirmed by two reviewers, who extracted all the data from the papers included accordingly for the standard meta-analysis.
The study included 12 eligible investigations covering 1388 patients, with the pooled risk ratio (RR) estimating the effectiveness of the postoperational prostheses between the titanium and non-titanium group, with a combined RR of 1.12 (95% confidence interval (CI): 0.98-1.27, p = 0.09), as well as their stability, with a combined RR of 1.47 (95% CI: 0.76-2.84, p = 0.26).
我们研究中收集的论文表明，钛合金组与非钛合金组之间在声音传导效果及假体稳定性方面无显著差异。然而，需要进一步开展大样本随机对照试验以完善评估。
通过荟萃分析比较钛合金或非钛合金听骨成形术组中假体的声音传导效果及稳定性，以用于临床意义和应用。
在PubMed上检索之前比较钛合金与非钛合金假体患者听力状况的研究，并人工检索所有相关参考文献。两名审阅者独立确认研究的合格性，他们从纳入的论文中提取所有数据以进行标准荟萃分析。
该研究纳入了12项合格研究，涵盖1388例患者，汇总风险比（RR）用于评估钛合金组与非钛合金组术后假体的有效性，合并RR为1.12（95%置信区间（CI）：0.98 - 1.27，p = 0.09），以及它们的稳定性，合并RR为1.47（95%CI：0.76 - 2.84，p = 0.26）。
