托瑞米芬的I期研究。
A phase I study of toremifene.
作者信息
Tominaga T, Abe O, Izuo M, Nomura Y
机构信息
Tokyo Metropolitan Komagome Hospital, Japan.
出版信息
Breast Cancer Res Treat. 1990 Aug;16 Suppl:S27-9. doi: 10.1007/BF01807141.
PMID:2149281
Abstract
A Phase I study of the new antiestrogenic drug toremifene was carried out in 27 Japanese women, using oral doses of 10-480 mg per day for one or five days. Serum concentrations reached a dose-dependent maximum 2-6 hours after each oral administration. Side effects were generally mild.
摘要
对新型抗雌激素药物托瑞米芬进行了一项I期研究，该研究纳入了27名日本女性，采用每日口服10 - 480毫克的剂量，持续用药1天或5天。每次口服给药后2 - 6小时，血清浓度达到剂量依赖性峰值。副作用一般较轻。
Zotero 插件