Tominaga T, Abe O, Izuo M, Nomura Y
Tokyo Metropolitan Komagome Hospital, Japan.
Breast Cancer Res Treat. 1990 Aug;16 Suppl:S27-9. doi: 10.1007/BF01807141.
A Phase I study of the new antiestrogenic drug toremifene was carried out in 27 Japanese women, using oral doses of 10-480 mg per day for one or five days. Serum concentrations reached a dose-dependent maximum 2-6 hours after each oral administration. Side effects were generally mild.