Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Endocrine and Metabolic E-Institutes of Shanghai Universities (EISU) and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
Atherosclerosis. 2011 Jul;217(1):194-200. doi: 10.1016/j.atherosclerosis.2011.03.002. Epub 2011 Mar 10.
Adipocyte and epidermal fatty acid-binding protein (A-FABP, E-FABP) are cytoplasmic proteins which may play an important role in metabolic diseases. In the present study, we investigated the different association of A-FABP and E-FABP with metabolic syndrome (MetS) and coronary artery disease (CAD) in Chinese adults.
A total of 459 subjects (233 MetS and 226 non-MetS) who had undergone coronary angiography were enrolled in the present study. Serum A-FABP and E-FABP levels, glucose, lipid profiles and other biochemical markers were measured.
Both serum A-FABP and E-FABP levels were significantly higher in the MetS group than in the non-MetS group (P = 0.040 and 0.045, respectively). Only serum A-FABP levels in the CAD group were significantly higher than in the non-CAD group (12.30 ± 5.45 vs.10.94 ± 4.94 ng/mL, P= 0.008), and significantly increased with the increasing of number of disease vessels (P=0.004). Serum A-FABP levels were also associated with risk of CAD (odds ratio 2.956 [1.295-6.748]; P = 0.010). Adjusting for age, sex, and other conventional risk factors for CAD did not appreciably change the results. No difference was found in serum E-FABP levels between CAD status. Serum E-FABP levels were correlated with fasting and post load 2h plasma glucose, HbA1c, serum total cholesterol and LDL-C concentrations while serum A-FABP levels were correlated with fasting and post load 2h serum insulin concentrations and HOMA-IR (different P<0.05).
Our data indicated while both serum A-FABP and E-FABP levels had associations with MetS, only A-FABP was significantly associated with increased risk of CAD in Chinese adults.
脂肪细胞型脂肪酸结合蛋白（A-FABP）和表皮型脂肪酸结合蛋白（E-FABP）是两种胞质蛋白，它们可能在代谢性疾病中发挥重要作用。本研究旨在探讨中国人中 A-FABP 和 E-FABP 与代谢综合征（MetS）和冠心病（CAD）的不同相关性。
共纳入 459 例接受冠状动脉造影的受试者（233 例 MetS 和 226 例非 MetS）。检测血清 A-FABP 和 E-FABP 水平、血糖、血脂谱和其他生化标志物。
MetS 组血清 A-FABP 和 E-FABP 水平均明显高于非 MetS 组（P=0.040 和 0.045）。CAD 组血清 A-FABP 水平明显高于非 CAD 组（12.30±5.45 vs. 10.94±4.94ng/ml，P=0.008），且随病变血管数的增加而升高（P=0.004）。血清 A-FABP 水平与 CAD 风险相关（比值比 2.956[1.295-6.748]；P=0.010）。校正年龄、性别和其他 CAD 常规危险因素后，结果无明显变化。CAD 状态下血清 E-FABP 水平无差异。血清 E-FABP 水平与空腹和餐后 2 小时血浆葡萄糖、HbA1c、血清总胆固醇和 LDL-C 浓度相关，而血清 A-FABP 水平与空腹和餐后 2 小时血清胰岛素浓度和 HOMA-IR 相关（差异 P<0.05）。
本研究数据表明，血清 A-FABP 和 E-FABP 水平与 MetS 均相关，而仅 A-FABP 与中国成年人 CAD 风险增加显著相关。
