螺内酯与血管平滑肌中（+）-[³H]-伊拉地平及（-）-[³H]-去甲氧基维拉帕米结合位点的相互作用。
Interactions of spironolactone with (+)-[3H]-isradipine and (-)-[3H]-desmethoxyverapamil binding sites in vascular smooth muscle.
作者信息
Mironneau J, Sayet I, Rakotoarisoa L, Dacquet C, Mironneau C
机构信息
Laboratoire de Physiologie Cellulaire et Pharmacologie Moléculaire, INSERM Jeune Formation 88-13, Université de Bordeaux, France.
出版信息
Br J Pharmacol. 1990 Sep;101(1):6-7. doi: 10.1111/j.1476-5381.1990.tb12077.x.
Abstract
Spironolactone partially inhibited the specific binding of (+)-[3H]-isradipine and (-)-[3H]-desmethoxyverapamil to vascular smooth muscle membranes. It is suggested that spironolactone interacts at a binding site of the calcium channel complex and allosterically modulates ligand binding at receptor sites in the channel.
摘要
螺内酯部分抑制（+）-[³H]-伊拉地平及（-）-[³H]-去甲氧基维拉帕米与血管平滑肌膜的特异性结合。提示螺内酯在钙通道复合物的结合位点相互作用，并对通道中受体位点的配体结合产生变构调节作用。
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(+)-[3H]-PN 200-110 binding to cell membranes and intact strips of portal vein smooth muscle: characterization and modulation by membrane potential and divalent cations.（+）-[³H]-PN 200-110与细胞膜及门静脉平滑肌完整条带的结合：膜电位和二价阳离子的表征及调节作用
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