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螺内酯与血管平滑肌中（+）-[³H]-伊拉地平及（-）-[³H]-去甲氧基维拉帕米结合位点的相互作用。

Interactions of spironolactone with (+)-[3H]-isradipine and (-)-[3H]-desmethoxyverapamil binding sites in vascular smooth muscle.

作者信息

Mironneau J, Sayet I, Rakotoarisoa L, Dacquet C, Mironneau C

机构信息

Laboratoire de Physiologie Cellulaire et Pharmacologie Moléculaire, INSERM Jeune Formation 88-13, Université de Bordeaux, France.

出版信息

Br J Pharmacol. 1990 Sep;101(1):6-7. doi: 10.1111/j.1476-5381.1990.tb12077.x.

DOI:10.1111/j.1476-5381.1990.tb12077.x
PMID:2149292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1917651/
Abstract

Spironolactone partially inhibited the specific binding of (+)-[3H]-isradipine and (-)-[3H]-desmethoxyverapamil to vascular smooth muscle membranes. It is suggested that spironolactone interacts at a binding site of the calcium channel complex and allosterically modulates ligand binding at receptor sites in the channel.

摘要

螺内酯部分抑制（+）-[³H]-伊拉地平及（-）-[³H]-去甲氧基维拉帕米与血管平滑肌膜的特异性结合。提示螺内酯在钙通道复合物的结合位点相互作用，并对通道中受体位点的配体结合产生变构调节作用。

相似文献

1
Interactions of spironolactone with (+)-[3H]-isradipine and (-)-[3H]-desmethoxyverapamil binding sites in vascular smooth muscle.螺内酯与血管平滑肌中（+）-[³H]-伊拉地平及（-）-[³H]-去甲氧基维拉帕米结合位点的相互作用。
Br J Pharmacol. 1990 Sep;101(1):6-7. doi: 10.1111/j.1476-5381.1990.tb12077.x.
2
Selective modulation by membrane potential of desmethoxyverapamil binding to calcium channels in rat portal vein.膜电位对去甲氧基维拉帕米与大鼠门静脉钙通道结合的选择性调节作用
J Pharmacol Exp Ther. 1990 Dec;255(3):942-7.
3
(+)-[3H]-PN 200-110 binding to cell membranes and intact strips of portal vein smooth muscle: characterization and modulation by membrane potential and divalent cations.（+）-[³H]-PN 200-110与细胞膜及门静脉平滑肌完整条带的结合：膜电位和二价阳离子的表征及调节作用
Br J Pharmacol. 1989 May;97(1):256-62. doi: 10.1111/j.1476-5381.1989.tb11949.x.
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(-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines.（-）-[³H]去甲氧基维拉帕米标记脑和骨骼肌膜中的多种钙通道调节剂受体：通过温度和二氢吡啶进行区分。
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Comparison of binding of 3H-desmethoxyverapamil and 3H-mibefradil in vascular smooth muscle and heart membranes. Possible binding of mibefradil to a site distinct from the phenylalkylamine-binding site.3H-去甲氧基维拉帕米与3H-米贝拉地尔在血管平滑肌组织和心脏组织膜中的结合情况比较。米贝拉地尔可能与一个不同于苯烷基胺结合位点的位点相结合。
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Binding of [3H]isradipine (PN 200-110) on smooth muscle cell membranes from different bovine arteries.[3H]伊拉地平（PN 200 - 110）与不同牛动脉平滑肌细胞膜的结合。
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Effects of oxodipine and elgodipine on (+)-[3H]-isradipine binding to cardiac and vascular membranes: cardiovascular selectivity.奥索地平与依尔地平对（+）-[³H]-异搏定与心脏及血管膜结合的影响：心血管选择性
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Modulation of [3H]dihydropyridine binding by activation of protein kinase C in vascular smooth muscle.蛋白激酶C激活对血管平滑肌中[3H]二氢吡啶结合的调节作用。
Eur J Pharmacol. 1991 Nov 13;208(3):223-30. doi: 10.1016/0922-4106(91)90099-4.

本文引用的文献

1
Specific binding of [3H]nitrendipine to membranes from coronary arteries and heart in relation to pharmacological effects. Paradoxical stimulation by diltiazem.[3H]尼群地平与冠状动脉及心脏膜的特异性结合及其药理效应。地尔硫䓬的反常刺激作用。
Biochem Biophys Res Commun. 1982 Sep 16;108(1):110-7. doi: 10.1016/0006-291x(82)91838-1.
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Ligand: a versatile computerized approach for characterization of ligand-binding systems.配体：一种用于表征配体结合系统的通用计算机化方法。
Anal Biochem. 1980 Sep 1;107(1):220-39. doi: 10.1016/0003-2697(80)90515-1.
3
Spironolactone inhibition of contraction and calcium channels in rat portal vein.螺内酯对大鼠门静脉收缩及钙通道的抑制作用。
Br J Pharmacol. 1987 Nov;92(3):535-44. doi: 10.1111/j.1476-5381.1987.tb11354.x.
4
Desmethoxyverapamil-sensitive calcium channels in rat portal vein smooth muscle.大鼠门静脉平滑肌中对去甲氧基维拉帕米敏感的钙通道。
Eur J Pharmacol. 1989 Aug 22;167(2):265-74. doi: 10.1016/0014-2999(89)90587-6.
5
(+)-[3H]-PN 200-110 binding to cell membranes and intact strips of portal vein smooth muscle: characterization and modulation by membrane potential and divalent cations.（+）-[³H]-PN 200-110与细胞膜及门静脉平滑肌完整条带的结合：膜电位和二价阳离子的表征及调节作用
Br J Pharmacol. 1989 May;97(1):256-62. doi: 10.1111/j.1476-5381.1989.tb11949.x.
6
Analysis of the properties of binding of calcium-channel activators and inhibitors to dihydropyridine receptors in chick heart membranes.鸡心膜中钙通道激活剂和抑制剂与二氢吡啶受体结合特性的分析。
Circ Res. 1987 Sep;61(3):379-88. doi: 10.1161/01.res.61.3.379.
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Calcium antagonism and calcium entry blockade.钙拮抗作用与钙内流阻断
Pharmacol Rev. 1986 Dec;38(4):321-416.
8
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.一种利用蛋白质 - 染料结合原理对微克级蛋白质进行定量的快速灵敏方法。
Anal Biochem. 1976 May 7;72:248-54. doi: 10.1016/0003-2697(76)90527-3.