Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
Maturitas. 2011 Jun;69(2):137-40. doi: 10.1016/j.maturitas.2011.03.020. Epub 2011 Apr 14.
Over 1.5 billion adults worldwide are classified as either overweight or obese, with rates continuing to increase. Obese individuals are at an increased risk for multiple disease processes, particularly type-2 diabetes mellitus (T2DM). Obesity has a strong association with insulin resistance, hyperinsulinemia and glucose intolerance. Adiposity, both subcutaneous and visceral, has been proposed to contribute to insulin resistance, eventually leading to T2DM. Strong evidence exists, in both genders, for the increased glucose intolerance and incidence of T2DM with increasing weight gain. Conversely, weight loss is associated with improvement of glycemic control, insulin resistance and T2DM. Bariatric surgery has risen as a therapeutic option that provides exceptional reduction in overall weight and resolution of T2DM. However, bariatric surgery serves as one component of a multifaceted weight management strategy that is required for long-term success.
全球有超过 15 亿成年人被归类为超重或肥胖，且这一比例还在持续上升。肥胖人群患多种疾病的风险增加，尤其是 2 型糖尿病（T2DM）。肥胖与胰岛素抵抗、高胰岛素血症和葡萄糖耐量受损密切相关。脂肪组织，包括皮下脂肪和内脏脂肪，被认为与胰岛素抵抗有关，最终导致 T2DM。无论在男性还是女性中，都有强有力的证据表明，体重增加会导致葡萄糖耐量受损和 T2DM 的发病率增加。相反，体重减轻与血糖控制、胰岛素抵抗和 T2DM 的改善相关。减重手术已成为一种治疗选择，可显著降低总体体重并解决 T2DM 问题。然而，减重手术只是多方面体重管理策略的一个组成部分，该策略是长期成功所必需的。
