规律身体活动对女性成年后哮喘发病的影响。

The effects of regular physical activity on adult-onset asthma incidence in women.

机构信息

Centre for Research in Environmental Epidemiology, Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain.

出版信息

Respir Med. 2011 Jul;105(7):1104-7. doi: 10.1016/j.rmed.2011.03.016. Epub 2011 Apr 13.

DOI:10.1016/j.rmed.2011.03.016

PMID:21493054

Abstract

BACKGROUND

Potential benefit of physical activity in asthma incidence is scarce and controversial. We aimed to assess the association between regular physical activity and adult-onset asthma.

METHODS

We included 51,080 women from a French cohort study, and followed them from 1993 to 2003. Physical activity at baseline was defined as time spent in household and leisure time physical activity, converted to metabolic equivalents (METs), and categorised in tertiles. Adult-onset asthma during follow-up was defined according to the American Thoracic Society criteria.

RESULTS

Mean age at baseline was 53 years, 13% of women were current smokers, 19% were overweight or obese, and 56% were postmenopausal; 512 (1%) developed asthma. No association was found between physical activity and asthma incidence in the crude or in the adjusted Cox regression model (adjusted HR 1.03 and 1.01 for the 2nd and 3rd tertiles compared to the 1st tertile, p for trend = 0.979).

CONCLUSION

Physical activity is not related to adult-onset asthma in this cohort of French middle-aged women.

摘要

背景

体力活动对哮喘发病率的潜在益处尚不清楚且存在争议。我们旨在评估规律体力活动与成年起病哮喘之间的关联。

方法

我们纳入了一项法国队列研究中的 51080 名女性，并随访至 1993 年至 2003 年。基线时的体力活动定义为在家务和休闲时间进行的体力活动所花费的时间，换算为代谢当量（METs），并分为三分位。随访期间根据美国胸科学会标准定义成年起病哮喘。

结果

基线时的平均年龄为 53 岁，13%的女性为当前吸烟者，19%为超重或肥胖，56%为绝经后；512 名（1%）发生哮喘。在未校正和校正的 Cox 回归模型中，体力活动与哮喘发病率均无关联（与第 1 三分位相比，第 2 和第 3 三分位的校正 HR 分别为 1.03 和 1.01，趋势检验 p = 0.979）。