Université Lille Nord de France, UDSL, Ibis Rue Georges Lefevre 59000 Lille, France.
Clin Neurophysiol. 2011 Oct;122(10):1991-2002. doi: 10.1016/j.clinph.2011.03.014. Epub 2011 Apr 13.
Cognitive event-related potentials (especially P300) have long been used to explore attentional processes. The aim of this study was to identify the cortical areas involved in P300 generation during a selective attention task.
128 channel electroencephalograms were recorded in 15 healthy controls performing a three-stimulus visual oddball paradigm, in order to identify distracter- and target-elicited P300 components. For each subject, the P300 sources were localized using standardized weighted low-resolution electromagnetic tomography (swLORETA). One sample and paired T-tests were performed using SPM5®.
Common sources for both P300 components were observed within a large frontoparietal network, including the frontal eye field and dorsal parietal cortex (i.e. the attentional dorsal frontoparietal network). More inferior parietal areas, prefrontal and cingulate cortices (i.e. the attentional ventral frontoparietal network) were also involved in the generation of target-elicited P300.
These results suggest that distracter- and target-elicited P300 are both generated by the dorsal frontoparietal network. Moreover, target processing recruits a specific ventral network.
Our data agree with the literature reports using other methods and should help to improve our knowledge of the cerebral networks underlying attentional processes.
认知事件相关电位（尤其是 P300）长期以来一直被用于探索注意力过程。本研究旨在确定在选择性注意任务中产生 P300 时涉及的皮质区域。
为了识别分散刺激和目标刺激引起的 P300 成分，15 名健康对照者在执行三刺激视觉Oddball 范式时记录了 128 通道脑电图。对于每个受试者，使用标准化加权低分辨率电磁断层扫描（swLORETA）定位 P300 源。使用 SPM5®进行单样本和配对 T 检验。
两种 P300 成分的共同源都在一个大的额顶网络中观察到，包括额眼区和背顶叶皮层（即注意背额顶叶网络）。更下顶叶区域、前额叶和扣带回皮层（即注意腹侧额顶叶网络）也参与了目标诱发 P300 的产生。
这些结果表明，分散刺激和目标刺激诱发的 P300 均由背额顶叶网络产生。此外，目标处理还募集了特定的腹侧网络。
我们的数据与使用其他方法的文献报道一致，应该有助于提高我们对注意力过程中脑网络的认识。
