高血压糖尿病大鼠小冠状动脉通透性与心肌损伤

Permeability of small coronary arteries and myocardial injury in hypertensive diabetic rats.

作者信息

Kubota I, Fukuhara T, Kinoshita M

机构信息

First Department of Internal Medicine, Shiga University of Medical Science, Ohtsu, Japan.

出版信息

Int J Cardiol. 1990 Dec;29(3):349-55. doi: 10.1016/0167-5273(90)90125-o.

DOI:10.1016/0167-5273(90)90125-o

PMID:2149364

Abstract

Damage to the coronary artery and myocardium is known to be more marked when hypertension is complicated by diabetes than when either is present alone. The reason is not clear, but one possible factor is vascular permeability. Therefore, we investigated vascular permeability using sodium fluorescein of 70 mg/kg body weight, in 12-week-old streptozotocin-induced diabetic spontaneously hypertensive rats. Non-diabetic spontaneously hypertensive rats, diabetic rats with normal blood pressure, and non-diabetic rats with normal blood pressure of the same age were used as controls and treated similarly. H-E and Azan staining were used to examine vascular abnormality and mycoardial damage. The diabetic spontaneously hypertensive rats showed marked sodium fluorescein in the coronary artery wall and surrounding area, demonstrating greater vascular permeability than non-diabetic spontaneously hypertensive rats, diabetic and non-diabetic normotensive rats. Heart weights and diameters of myocytes were smaller in the diabetic than in the non-diabetic spontaneously hypertensive rats. Diabetic spontaneously hypertensive rats also exhibited marked perivascular fibrosis and focal necrosis. Thus, increased vascular permeability may play a role in vascular and myocardial changes in diabetic spontaneously hypertensive rats.

摘要

已知高血压合并糖尿病时，冠状动脉和心肌的损伤比单独存在高血压或糖尿病时更为明显。原因尚不清楚，但一个可能的因素是血管通透性。因此，我们使用70mg/kg体重的荧光素钠，对12周龄链脲佐菌素诱导的糖尿病自发性高血压大鼠的血管通透性进行了研究。非糖尿病自发性高血压大鼠、血压正常的糖尿病大鼠和同龄血压正常的非糖尿病大鼠作为对照，并进行类似处理。采用苏木精-伊红（H-E）染色和阿赞染色检查血管异常和心肌损伤。糖尿病自发性高血压大鼠的冠状动脉壁和周围区域显示出明显的荧光素钠，表明其血管通透性高于非糖尿病自发性高血压大鼠、糖尿病和非糖尿病血压正常大鼠。糖尿病大鼠的心脏重量和心肌细胞直径比非糖尿病自发性高血压大鼠小。糖尿病自发性高血压大鼠还表现出明显的血管周围纤维化和局灶性坏死。因此，血管通透性增加可能在糖尿病自发性高血压大鼠的血管和心肌变化中起作用。