Department of Nuclear Medicine,Technische Universität München, München, Germany.
Clin Cancer Res. 2011 Jun 1;17(11):3751-9. doi: 10.1158/1078-0432.CCR-10-2093. Epub 2011 Apr 14.
To evaluate the dependency of the sensitivity of [(11)C]choline positron emission tomography/computed tomography (PET/CT) for detecting and localizing primary prostate cancer (PCa) on tumor configuration in the histologic specimen.
Forty-three patients with biopsy-proven PCa were included. They underwent radical prostatectomy within 31 days after [(11)C]choline PET/CT. The transaxial image slices and the histologic specimens were analyzed by comparing the respective slices. Maximum standardized uptake values (SUV(max)) were calculated in each segment and correlated with histopathology. The tumor configuration in the histologic specimen was grouped as: I, unifocal; II, multifocal; III, rind-like shaped; IV, size <5 mm. Data analysis included the investigation of detection of PCa by SUV(max), the assessment of the influence of potential contributing factors on tumor prediction, and the evaluation of whether SUV could discriminate cancer tissue from benign prostate hyperplasia (BPH), prostatitis, HGPIN (high-grade prostate intraepithelial neoplasm), or normal prostate tissue. General estimation equation models were used for statistical analysis.
Tumor configuration in histology was classified as I in 21 patients, as II in 9, as III in 5, and as IV in 8. The prostate segment involved by cancer is identified in 79% of the patients. SUV(max) was located in the same side of the prostate in 95% of patients. Tumor configuration was the only factor significantly negatively influencing tumor prediction (P < 0.001). PCa-SUV(max) (median SUV(max) = 4.9) was not significantly different from BPH-SUV (median SUV(max) = 4.5) and prostatitis-SUV (median SUV(max) = 3.9), P = 0.102 and P = 0.054, respectively.
The detection and localization of PCa in the prostate with [(11)C]choline PET/CT is impaired by tumor configuration. Additionally, in our patient population, PCa tissue could not be distinguished from benign pathologies in the prostate.
评估[(11)C]胆碱正电子发射断层扫描/计算机断层扫描（PET/CT）检测和定位原发性前列腺癌（PCa）的敏感性对肿瘤在组织学标本中的形态的依赖性。
纳入 43 例经活检证实的 PCa 患者。他们在[(11)C]胆碱 PET/CT 后 31 天内接受根治性前列腺切除术。通过比较相应的切片，对横轴图像切片和组织学标本进行分析。在每个节段计算最大标准化摄取值（SUV(max)），并与组织病理学相关联。在组织学标本中，肿瘤形态分为：I 型，单发；II 型，多发；III 型，包绕型；IV 型，<5mm。数据分析包括 SUV(max)检测 PCa 的情况、评估潜在影响肿瘤预测的因素的影响，以及评估 SUV 是否可以区分癌组织与良性前列腺增生（BPH）、前列腺炎、HGPIN（高级别前列腺上皮内瘤变）或正常前列腺组织。采用广义估计方程模型进行统计分析。
组织学中的肿瘤形态在 21 例患者中为 I 型，在 9 例患者中为 II 型，在 5 例患者中为 III 型，在 8 例患者中为 IV 型。79%的患者可以识别前列腺中受癌症累及的节段。95%的患者中 SUV(max)位于前列腺的同一侧。肿瘤形态是唯一显著负向影响肿瘤预测的因素（P < 0.001）。PCa-SUV(max)（中位数 SUV(max) = 4.9）与 BPH-SUV（中位数 SUV(max) = 4.5）和前列腺炎-SUV（中位数 SUV(max) = 3.9）无显著差异，P = 0.102 和 P = 0.054。
[(11)C]胆碱 PET/CT 检测和定位前列腺内的 PCa 受到肿瘤形态的影响。此外，在我们的患者人群中，PCa 组织与前列腺中的良性病变无法区分。
Zotero 插件