NITIN GUPTA, M.D., Senior Resident, Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh - 160012.
Indian J Psychiatry. 1998 Oct;40(4):322-6.
Response to first ECT in depression and its value as a predictor of response to ECT is a poorly researched subject. Twenty-two antidepressant-free patients of severe depression (ICD - 10) were administered a course of 6 ECTs using bilateral sine-wave electrical stimulation with serial assessments on Hamilton Depression Rating Scale (HDRS). Using 'a priori' definition for 'good response' (≥ 60% reduction is baseline HDRS scores) patients were grouped and analysed. The reduction in HDRS scores after first ECT was significantly greater for Good Responders (GR) in comparison to 'Poor responders'. It appeared that ≥ 9% reduction in baseline HDRS scores after the first ECT was associated with 'Good Response'. Thus, it can be concluded that response to first ECT could be taken as a viable predictor of response in depression.
首次电抽搐治疗（ECT）在抑郁症中的反应及其作为 ECT 反应预测因子的价值是一个研究不足的课题。22 名严重抑郁症（ICD-10）且未服用抗抑郁药物的患者接受了 6 次双侧正弦波电刺激ECT 治疗，采用汉密尔顿抑郁量表（HDRS）进行连续评估。使用“事先”定义的“良好反应”（基线 HDRS 评分降低≥60%）对患者进行分组和分析。与“反应不佳者”相比，首次 ECT 后 HDRS 评分的降低在“反应良好者”（GR）中更为显著。似乎在首次 ECT 后基线 HDRS 评分降低≥9%与“良好反应”相关。因此，可以得出结论，首次 ECT 的反应可以作为抑郁症反应的一个可行预测因子。
