P.N. SURESH KUMAR, M.D., DPM, DNB(Psych.), MNAMS, Lecturer, Department of Psychiatry, Medical College, Calicut.
Indian J Psychiatry. 1998 Oct;40(4):357-63.
This prospective study was conducted to assess the prevalence of substance abuse comorbidity and its impact on psycho pathology and pattern of remission in mania. Hundred consecutive inpatients with a diagnosis of manic episode were followed up for three months using structured clinical interview schedule for DSM III R (SCID-P), DSM IIIR check list for mania. Bech-Rafaelsan Mania Rating Scale and a questionnaire concerning sociodemographic and clinical profile. The prevalence of substance abuse comorbidity was 52%. Substance abusers were significantly younger, had early age of onset of mood disorder, unmarried, unemployed, had more dysphoric and irritate mood states and grandiose and persecutory delusions. Risk factor analysis showed substance abuse as being consistently associated with poor outcome in mania.
这项前瞻性研究旨在评估物质滥用共病的患病率及其对躁狂症患者精神病理学和缓解模式的影响。采用 DSM-III-R 结构临床访谈表 (SCID-P)、DSM-III-R 躁狂症检查表、Bech-Rafaelsan 躁狂症评定量表以及一份有关社会人口统计学和临床特征的问卷，对 100 例确诊为躁狂发作的住院患者进行了为期 3 个月的随访。物质滥用共病的患病率为 52%。物质滥用者的年龄明显较小，心境障碍的发病年龄更早，未婚、失业，情绪状态更易激惹、烦躁，夸大妄想和被害妄想更为常见。风险因素分析表明，物质滥用与躁狂症的不良预后密切相关。
