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印度共病大麻使用障碍和精神障碍研究述评。

A review of Indian research on co-occurring cannabis use disorders& psychiatric disorders.

机构信息

Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.

Department of Psychiatry; National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Indian J Med Res. 2017 Aug;146(2):186-195. doi: 10.4103/ijmr.IJMR_791_15.

Abstract

BACKGROUND & OBJECTIVES: Cannabis is a widely used illicit drug and its use is often associated with co-occurring psychiatric disorders. This systematic review was aimed to provide information on the published Indian studies on co-occurring cannabis use disorders and psychiatric disorders.

METHODS

An electronic search of available Indian literature using relevant search terms was carried out in May 2015 and 52 articles in English language published from India were included in the current review.

RESULTS

Studies on cannabis and associated psychotic disorders (n=16) chiefly described acute episodes with predominant positive symptoms, following cannabis use. Some studies (n=6) observed an overall increased prevalence of all psychiatric disorders and symptoms owing to cannabis use, while others (n=14) elaborated on high rates of substance use in those with psychiatric disorders. The effect of cannabis use on cognitive function was the focus of some of the Indian studies (n=7). All these studies barring one had all male subjects, and a single study described the service delivery model for those with dual diagnosis disorders in India. Most of the research used cross-sectional observational design and focussed on treatment-seeking population.

INTERPRETATION & CONCLUSIONS: A review of Indian literature on cannabis use and its association with psychiatric disorders indicates a high co-prevalence of psychotic disorders, especially in vulnerable individuals as well as high rates of co-occurrence of other psychiatric comorbidities. However, there is limited focus on exploring the aetiological association between cannabis use and psychiatric disorders; understanding the neurobiology of this association and management-related issues.

摘要

背景与目的

大麻是一种广泛使用的非法药物,其使用通常与同时发生的精神障碍有关。本系统评价旨在提供已发表的关于印度大麻使用障碍和精神障碍共病的研究信息。

方法

于 2015 年 5 月使用相关检索词对印度现有文献进行电子检索,纳入了来自印度的 52 篇英文文章。

结果

关于大麻和相关精神病障碍的研究(n=16)主要描述了使用大麻后出现的以阳性症状为主的急性发作。一些研究(n=6)观察到由于使用大麻,所有精神障碍和症状的总体患病率增加,而其他研究(n=14)则详细阐述了精神障碍患者中物质使用的高发生率。一些印度研究(n=7)关注了大麻使用对认知功能的影响。除了一项研究之外,所有这些研究都仅纳入了男性受试者,而一项研究描述了印度双诊断障碍患者的服务提供模式。大多数研究采用横断面观察性设计,重点关注寻求治疗的人群。

结论

对印度关于大麻使用及其与精神障碍关系的文献的综述表明,精神病障碍的共病率很高,尤其是在易受影响的个体中,以及其他精神共病的发生率也很高。然而,对于探索大麻使用与精神障碍之间的病因学关联、理解这种关联的神经生物学以及管理相关问题,关注有限。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e484/5761028/ec07f2458695/IJMR-146-186-g003.jpg

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