Buell J S, Tucker K L
Harvard Clinical Research Institute, Boston, Massachusetts, USA.
Drugs Today (Barc). 2011 Mar;47(3):223-31. doi: 10.1358/dot.2011.47.3.1517492.
Vitamin D has been investigated in association with cognitive function in healthy and multimorbid elderly patients. Whether higher physiologic concentrations of vitamin D may be neuroprotective is not yet known. Epidemiological investigations have suggested a protective effect of physiologic vitamin D concentrations (circulating 25-hydroxyvitamin D) on neurocognitive dysfunction and cerebrovascular disease. Recent prospective studies have shown a beneficial association of vitamin D with a myriad of health conditions and suggest that vitamin D may be neuroprotective via vascular mechanisms. Whether vitamin D concentrations are a useful indicator for the identification and clinical management of dementia remains to be determined. On its own, physiological vitamin D status may be an important risk indicator for several comorbidities; however, further studies are required to determine if physiological vitamin D can be used as a biomarker in the clinical determination and disease management of dementia.
维生素D已在健康和多病的老年患者中与认知功能相关联进行了研究。更高的生理浓度维生素D是否具有神经保护作用尚不清楚。流行病学调查表明生理浓度的维生素D（循环中的25-羟基维生素D）对神经认知功能障碍和脑血管疾病具有保护作用。最近的前瞻性研究表明维生素D与多种健康状况存在有益关联，并表明维生素D可能通过血管机制具有神经保护作用。维生素D浓度是否是痴呆症识别和临床管理的有用指标仍有待确定。就其本身而言，生理维生素D状态可能是几种合并症的重要风险指标；然而，需要进一步研究以确定生理维生素D是否可作为痴呆症临床诊断和疾病管理的生物标志物。
