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三甲基取代荧光萘啶作为 CCG 三核苷酸重复中 C-C 错配检测的配体。

Fluorescent trimethyl-substituted naphthyridine as a ligand for C-C mismatch detection in CCG trinucleotide repeats.

机构信息

Department of Chemistry, Graduate School of Science, Tohoku University, Japan, Sendai 980-8578, Japan.

出版信息

Chem Commun (Camb). 2011 May 28;47(20):5885-7. doi: 10.1039/c1cc11370d. Epub 2011 Apr 14.

DOI:10.1039/c1cc11370d
PMID:21494727
Abstract

We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C-C mismatch present in the hairpin structures of (CCG)(n) trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.

摘要

我们报告了 2-氨基-5,6,7-三甲基-1,8-萘啶（ATMND）与存在于与神经疾病相关的发夹结构中的 C-C 错配的选择性结合；这种结合伴随着 ATMND 的显著荧光猝灭。

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