Kuhn A, Ruland V, Bonsmann G
Klinik und Poliklinik für Hautkrankheiten, Universitätsklinikum Münster, Münster, Deutschland.
Z Rheumatol. 2011 Apr;70(3):213-26; quiz 227. doi: 10.1007/s00393-011-0789-3.
Lupus erythematosus (LE) is an inflammatory autoimmune disorder, which is characterized by clinically heterogeneous manifestations of different organs. In systemic LE (SLE) the skin, the musculoskeletal system, the kidneys, the cardiovascular and central nervous systems can be involved. The skin lesions can be divided into LE-specific and LE-non-specific manifestations, the former represent the subtypes of cutaneous LE (CLE). The diagnosis is confirmed by clinical, histopathological, immunoserological and genetic features. The treatment is similar for the different subtypes of CLE; however, the therapeutic regimen should be individually defined in each patient. Antimalarials are still the first-line systemic therapy and in addition to sunscreens, glucocorticosteroids and calcineurin inhibitors have an important impact as topical agents in this disease.
红斑狼疮（LE）是一种炎症性自身免疫性疾病，其特征是不同器官出现临床异质性表现。在系统性红斑狼疮（SLE）中，皮肤、肌肉骨骼系统、肾脏、心血管和中枢神经系统均可受累。皮肤病变可分为LE特异性和LE非特异性表现，前者代表皮肤型红斑狼疮（CLE）的亚型。通过临床、组织病理学、免疫血清学和遗传学特征确诊。CLE不同亚型的治疗方法相似；然而，应针对每位患者单独确定治疗方案。抗疟药仍然是一线全身治疗药物，除了使用防晒霜外，糖皮质激素和钙调神经磷酸酶抑制剂作为局部用药在这种疾病中也有重要作用。
