Department of Dermatology, University of Muenster, Muenster, Germany.
J Am Acad Dermatol. 2011 Jan;64(1):37-48. doi: 10.1016/j.jaad.2009.12.053.
We sought to assess if the exclusive use of a broad-spectrum sunscreen can prevent skin lesions in patients with different subtypes of cutaneous lupus erythematosus (CLE) induced by ultraviolet (UV) irradiation under standardized conditions.
A total of 25 patients with a medical history of photosensitive CLE were included in this monocentric, randomized, vehicle-controlled, double-blind, intraindividual study. The test product and its vehicle were applied 15 minutes before UVA and UVB irradiation of uninvolved skin areas on the upper aspect of the back in a random order, and standardized phototesting was performed daily for 3 consecutive days.
Characteristic skin lesions were induced by UVA and UVB irradiation in 16 patients with CLE in the untreated area, and 14 patients showed a positive test result in the vehicle-treated area. In contrast, no eruptions compatible with CLE were observed in the sunscreen-treated area in any of the 25 patients. This resulted in significant differences (P < .001) between UV-irradiated sunscreen-treated versus vehicle-treated areas, and between UV-irradiated sunscreen-treated versus untreated areas. Furthermore, a significant difference (P < .05) was observed concerning the age of disease onset and the patient history of photosensitivity. Patients who were younger than 40 years at onset of CLE reported photosensitivity significantly more often than patients with a higher age of disease onset. None of the patients showed any adverse events from application of the test product or the vehicle.
Data resulting from standardized experimental phototesting might not be transferable to a clinical setting.
These results indicate clearly that the use of a highly protective broad-spectrum sunscreen can prevent skin lesions in photosensitive patients with different subtypes of CLE.
我们旨在评估在标准化条件下，仅使用广谱防晒霜是否可以预防不同亚类的光化性类狼疮患者（CLE）因紫外线（UV）照射引起的皮肤损伤。
这项单中心、随机、赋形剂对照、双盲、个体内研究共纳入了 25 例有光敏性 CLE 病史的患者。测试产品及其赋形剂在 UVA 和 UVB 照射未受累背部上半部分的皮肤前 15 分钟，以随机顺序应用，并且每日进行标准化光测试，持续 3 天。
在未治疗区域，16 例 CLE 患者出现了 UVA 和 UVB 照射诱导的特征性皮肤损伤，在接受赋形剂治疗的区域，14 例患者出现了阳性测试结果。相比之下，在任何 25 例患者的防晒霜治疗区域中，均未观察到与 CLE 相符的皮疹。这导致了在 UV 照射的防晒霜治疗区域与赋形剂治疗区域之间，以及在 UV 照射的防晒霜治疗区域与未治疗区域之间存在显著差异（P <.001）。此外，在疾病发病年龄和患者光敏性病史方面也观察到了显著差异（P <.05）。发病年龄小于 40 岁的患者比发病年龄较高的患者更常报告光敏性。任何患者在应用测试产品或赋形剂时均未出现任何不良反应。
标准化实验光测试得出的数据可能无法转移到临床环境中。
这些结果清楚地表明，使用高防护广谱防晒霜可以预防不同亚类的光敏性 CLE 患者的皮肤损伤。
