Pihko Petri M, Majander Inkeri, Erkkilä Anniina
Department of Chemistry, University of Jyväskylä, P. O. B. 35, FI-40014 JYU, Jyväskylä, Finland.
Top Curr Chem. 2010;291:29-75. doi: 10.1007/978-3-642-02815-1_21.
The reversible reaction of primary or secondary amines with enolizable aldehydes or ketones affords nucleophilic intermediates, enamines. With chiral amines, catalytic enantioselective reactions via enamine intermediates become possible. In this review, structure-activity relationships and the scope as well as current limitations of enamine catalysis are discussed.
伯胺或仲胺与可烯醇化的醛或酮的可逆反应会生成亲核中间体烯胺。使用手性胺时，通过烯胺中间体进行催化对映选择性反应成为可能。在本综述中，将讨论烯胺催化的构效关系、适用范围以及当前的局限性。
