Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology, University of Iowa, Iowa City, Iowa 52242, USA.
Laryngoscope. 2011 Jun;121(6):1184-6. doi: 10.1002/lary.21778. Epub 2011 Apr 14.
Several mitochondrial DNA variants increase risk for developing sensorineural hearing loss following exposure to aminoglycoside antibiotics, a particular concern in the premature infant population, as many of these babies spend time in neonatal intensive care units and are treated with aminoglycosides. To determine the relative prevalence of five mitochondrial DNA variants in the 12S rRNA gene, MT-RNR1, we genotyped 703 neonatal intensive care unit patients and 1473 individuals from the general Iowa population. We found that the aggregate frequency of these variants (∼1.8%) was comparable between populations. Although no hearing loss was detected by newborn hearing screens in the at-risk patients, these neonatal intensive care unit graduates have an increased life-time risk for developing aminoglycoside-induced deafness.
几种线粒体 DNA 变异会增加接触氨基糖苷类抗生素后发生感音神经性听力损失的风险，这在早产儿群体中是一个特别值得关注的问题，因为许多早产儿都在新生儿重症监护病房接受治疗，并使用氨基糖苷类药物。为了确定 12S rRNA 基因和 MT-RNR1 中五个线粒体 DNA 变异的相对流行率，我们对 703 名新生儿重症监护病房患者和 1473 名来自爱荷华州一般人群的个体进行了基因分型。我们发现，这些变异的总频率（约 1.8%）在人群之间是可比的。尽管在高危患者中，新生儿听力筛查未发现听力损失，但这些新生儿重症监护病房的毕业生终生患氨基糖苷类药物诱导性耳聋的风险增加。
