Pain & Autonomics-Integrative Research (PAIR), Department of Psychiatry and Psychotherapy, University Hospital Jena, Jena, Germany.
Psychophysiology. 2011 Oct;48(10):1323-32. doi: 10.1111/j.1469-8986.2011.01210.x. Epub 2011 Apr 15.
We investigated to what degree tonic skin conductance levels (SCL) and cardiac autonomic dysfunction are interrelated in schizophrenia. Heart rate variability (HRV) and SCL were simultaneously assessed in 18 unmedicated patients and 18 controls matched for age, sex, weight, and smoking habits. For comparison to prior studies, phasic sympathetic skin responses (SPR) were also recorded. Compared to controls, patients had prolonged SPR latency and reduced SPR amplitude with a right-greater-than-left asymmetry, which was inversely correlated with positive symptoms. An autonomic imbalance was reflected in linear and nonlinear measures of HRV and increased SCL. Patients showed a stronger nonlinear association between SCL and heart rate than controls. HRV and SCL findings were strongly affected by group differences in breathing rate. Stronger HRV-SCL coupling in patients may suggest augmented sympathetic modulation in schizophrenia.
我们研究了在精神分裂症中，紧张性皮肤电导率（SCL）和心脏自主功能障碍的关联程度。我们对 18 名未接受药物治疗的患者和 18 名年龄、性别、体重和吸烟习惯相匹配的对照组同时进行了心率变异性（HRV）和 SCL 的评估。为了与之前的研究进行比较，我们还记录了阶段性交感皮肤反应（SPR）。与对照组相比，患者的 SPR 潜伏期延长，SPR 幅度减小，右侧大于左侧的不对称性增加，这与阳性症状呈负相关。HRV 和 SCL 的线性和非线性测量反映了自主神经失衡，并伴有 SCL 升高。与对照组相比，患者的 SCL 和心率之间存在更强的非线性关联。HRV 和 SCL 的发现受到呼吸率组间差异的强烈影响。患者的 HRV-SCL 耦合更强，可能表明精神分裂症中交感神经调节增强。
