van Diest Sophie A, Stanisor Oana I, Boeckxstaens Guy E, de Jonge Wouter J, van den Wijngaard René M
Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.
Biochim Biophys Acta. 2012 Jan;1822(1):74-84. doi: 10.1016/j.bbadis.2011.03.019. Epub 2011 Apr 7.
Cross-talk between the immune- and nervous-system is considered an important biological process in health and disease. Because mast cells are often strategically placed between nerves and surrounding (immune)-cells they may function as important intermediate cells. This review summarizes the current knowledge on bidirectional interaction between mast cells and nerves and its possible relevance in (inflammation-induced) increased nociception. Our main focus is on mast cell mediators involved in sensitization of TRP channels, thereby contributing to nociception, as well as neuron-released neuropeptides and their effects on mast cell activation. Furthermore we discuss mechanisms involved in physical mast cell-nerve interactions. This article is part of a Special Issue entitled: Mast cells in inflammation.
免疫系统与神经系统之间的相互作用被认为是健康和疾病中一个重要的生物学过程。由于肥大细胞常常策略性地分布于神经与周围（免疫）细胞之间，它们可能起到重要的中间细胞作用。本综述总结了目前关于肥大细胞与神经之间双向相互作用及其在（炎症诱导的）痛觉过敏中可能相关性的知识。我们主要关注参与瞬时受体电位（TRP）通道敏化从而导致痛觉的肥大细胞介质，以及神经元释放的神经肽及其对肥大细胞激活的影响。此外，我们还讨论了肥大细胞与神经物理相互作用的机制。本文是名为《炎症中的肥大细胞》特刊的一部分。
