Buhner Sabine, Schemann Michael
Human Biology, Technische Universität München, Germany.
Biochim Biophys Acta. 2012 Jan;1822(1):85-92. doi: 10.1016/j.bbadis.2011.06.004. Epub 2011 Jun 17.
This paper summarizes the current knowledge on the interactions between intestinal mast cells, enteric neurons and visceral afferents which are part of the gut brain axis. The focus of this review is on the relevance of the mast cell-nerve axis in the human intestine. Similarities and important differences in the organization of the mast cell-nerve axis between human and rodents are discussed. Functionally important human mast cell mediators with neural actions in the human ENS are histamine (H1-4 receptors), proteases (PAR1 receptors), several cytokines and chemokines and probably also serotonin (5-HT(3) receptors). On the other hand, mediator release from human intestinal mast cells is modulated by neuropeptides released from enteric and visceral afferent nerves. This article is part of a Special Issue entitled: Mast Cells in Inflammation.
本文总结了目前关于肠道肥大细胞、肠神经元和内脏传入神经之间相互作用的知识，这些都是肠脑轴的组成部分。本综述的重点是肥大细胞-神经轴在人类肠道中的相关性。讨论了人类和啮齿动物之间肥大细胞-神经轴组织的异同。在人类肠神经系统中具有神经作用的重要人类肥大细胞介质包括组胺（H1-4受体）、蛋白酶（PAR1受体）、几种细胞因子和趋化因子，可能还有5-羟色胺（5-HT(3)受体）。另一方面，人类肠道肥大细胞的介质释放受肠和内脏传入神经释放的神经肽调节。本文是名为《炎症中的肥大细胞》特刊的一部分。
