真菌交配信息素：编排求偶游戏。
Fungal mating pheromones: choreographing the dating game.
机构信息
Graduate Program in Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, United States.
出版信息
Fungal Genet Biol. 2011 Jul;48(7):668-76. doi: 10.1016/j.fgb.2011.04.001. Epub 2011 Apr 8.
Abstract
Pheromones are ubiquitous from bacteria to mammals - a testament to their importance in regulating inter-cellular communication. In fungal species, they play a critical role in choreographing interactions between mating partners during the program of sexual reproduction. Here, we describe how fungal pheromones are synthesized, their interactions with G protein-coupled receptors, and the signals propagated by this interaction, using Saccharomyces cerevisiae as a reference point. Divergence from this model system is compared amongst the ascomycetes and basidiomycetes, which reveals the wealth of information that has been gleaned from studying pheromone-driven processes across a wide spectrum of the fungal kingdom.
摘要
信息素无处不在，从细菌到哺乳动物——这证明了它们在调节细胞间通讯方面的重要性。在真菌物种中，它们在性生殖过程中协调交配伴侣之间的相互作用中起着关键作用。在这里，我们描述了真菌信息素的合成方式、它们与 G 蛋白偶联受体的相互作用以及这种相互作用所传播的信号，以酿酒酵母作为参考点。与这个模型系统的差异在子囊菌和担子菌中进行了比较，这揭示了从研究广泛的真菌王国中信息素驱动的过程中获得的丰富信息。
相似文献
1
Fungal mating pheromones: choreographing the dating game.
Fungal Genet Biol. 2011 Jul;48(7):668-76. doi: 10.1016/j.fgb.2011.04.001. Epub 2011 Apr 8.
2
Asymmetry in sexual pheromones is not required for ascomycete mating.
Curr Biol. 2011 Aug 23;21(16):1337-46. doi: 10.1016/j.cub.2011.06.054. Epub 2011 Aug 11.
3
Basidiomycete mating type genes and pheromone signaling.
Eukaryot Cell. 2010 Jun;9(6):847-59. doi: 10.1128/EC.00319-09. Epub 2010 Feb 26.
4
Mating in mushrooms: increasing the chances but prolonging the affair.
Trends Genet. 2001 Jul;17(7):393-400. doi: 10.1016/s0168-9525(01)02343-5.
5
Tetrapolar fungal mating types: sexes by the thousands.
FEMS Microbiol Rev. 1996 Mar;18(1):65-87. doi: 10.1111/j.1574-6976.1996.tb00227.x.
6
Phospholipase D1 is required for efficient mating projection formation in Saccharomyces cerevisiae.
FEMS Yeast Res. 2001 Dec;1(3):225-32. doi: 10.1111/j.1567-1364.2001.tb00038.x.
7
Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response.
J Biol Chem. 2016 Apr 8;291(15):7788-95. doi: 10.1074/jbc.R116.714980. Epub 2016 Feb 23.
8
Pheromone responsiveness is regulated by components of the Gpr1p-mediated glucose sensing pathway in Saccharomyces cerevisiae.
Yeast. 2014 Sep;31(9):361-74. doi: 10.1002/yea.3030. Epub 2014 Jul 25.
9
Chemotropism during yeast mating.
Methods Mol Biol. 2009;571:99-110. doi: 10.1007/978-1-60761-198-1_6.
10
Combining mutations in the incoming and outgoing pheromone signal pathways causes a synergistic mating defect in Saccharomyces cerevisiae.
Yeast. 1999 Jun 30;15(9):765-80. doi: 10.1002/(SICI)1097-0061(19990630)15:9<765::AID-YEA418>3.0.CO;2-4.
引用本文的文献
1
Three-Dimensional Structural Heteromorphs of Mating-Type Proteins in and the Natural Insect-Fungal Complex.
J Fungi (Basel). 2025 Mar 23;11(4):244. doi: 10.3390/jof11040244.
2
A mass spectrometry-based strategy for investigating volatile molecular interactions in microbial consortia: unveiling a -specific induction of an antifungal compound.
Front Microbiol. 2025 Feb 25;15:1417919. doi: 10.3389/fmicb.2024.1417919. eCollection 2024.
3
Mutations and Differential Transcription of Mating-Type and Pheromone Receptor Genes in and the Natural Insect-Fungi Complex.
Biology (Basel). 2024 Aug 18;13(8):632. doi: 10.3390/biology13080632.
4
Genetic modules for α-factor pheromone controlled growth regulation of .
Eng Life Sci. 2024 May 22;24(8):e2300235. doi: 10.1002/elsc.202300235. eCollection 2024 Aug.
5
A peroxidase-derived ligand that induces Ste2 receptor-dependent chemotropism.
Front Cell Infect Microbiol. 2024 Jan 4;13:1287418. doi: 10.3389/fcimb.2023.1287418. eCollection 2023.
6
Peptide Variant Detection by a Living Yeast Biosensor via an Epitope-Selective Protease.
Biodes Res. 2023 Mar 15;5:0003. doi: 10.34133/bdr.0003. eCollection 2023.
7
Needles in fungal haystacks: Discovery of a putative a-factor pheromone and a unique mating strategy in the Leotiomycetes.
PLoS One. 2023 Oct 12;18(10):e0292619. doi: 10.1371/journal.pone.0292619. eCollection 2023.
8
Extending the reach of homology by using successive computational filters to find yeast pheromone genes.
Curr Biol. 2023 Oct 9;33(19):4098-4110.e3. doi: 10.1016/j.cub.2023.08.039. Epub 2023 Sep 11.
9
Multi-stage nuclear transcriptomic insights of morphogenesis and biparental role changes in Lentinula edodes.
Appl Microbiol Biotechnol. 2023 Sep;107(17):5469-5489. doi: 10.1007/s00253-023-12624-y. Epub 2023 Jul 13.
10
Lessons on fruiting body morphogenesis from genomes and transcriptomes of .
Stud Mycol. 2023 Jul;104:1-85. doi: 10.3114/sim.2022.104.01. Epub 2023 Jan 31.
本文引用的文献
1
Ustilago maydis: how its biology relates to pathogenic development.
New Phytol. 2004 Oct;164(1):31-42. doi: 10.1111/j.1469-8137.2004.01156.x.
2
Evolutionary reshaping of fungal mating pathway scaffold proteins.
mBio. 2011 Jan 11;2(1):e00230-10. doi: 10.1128/mBio.00230-10.
3
Utilization of the mating scaffold protein in the evolution of a new signal transduction pathway for biofilm development.
mBio. 2011 Jan 11;2(1):e00237-10. doi: 10.1128/mBio.00237-10.
4
Establishing an unusual cell type: how to make a dikaryon.
Curr Opin Microbiol. 2010 Dec;13(6):706-11. doi: 10.1016/j.mib.2010.09.016. Epub 2010 Oct 29.
5
Identification of residue-to-residue contact between a peptide ligand and its G protein-coupled receptor using periodate-mediated dihydroxyphenylalanine cross-linking and mass spectrometry.
J Biol Chem. 2010 Dec 10;285(50):39425-36. doi: 10.1074/jbc.M110.149500. Epub 2010 Oct 4.
6
Regulation of cross-talk in yeast MAPK signaling pathways.
Curr Opin Microbiol. 2010 Dec;13(6):677-83. doi: 10.1016/j.mib.2010.09.001. Epub 2010 Sep 27.
7
A novel class of peptide pheromone precursors in ascomycetous fungi.
Mol Microbiol. 2010 Sep;77(6):1483-501. doi: 10.1111/j.1365-2958.2010.07295.x.
8
The transcription factor Rbf1 is the master regulator for b-mating type controlled pathogenic development in Ustilago maydis.
PLoS Pathog. 2010 Aug 5;6(8):e1001035. doi: 10.1371/journal.ppat.1001035.
9
Sexual reproduction in the Candida clade: cryptic cycles, diverse mechanisms, and alternative functions.
Cell Mol Life Sci. 2010 Oct;67(19):3275-85. doi: 10.1007/s00018-010-0421-8. Epub 2010 Jun 15.
10
Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling.
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11805-10. doi: 10.1073/pnas.1005817107. Epub 2010 Jun 14.
Zotero 插件