Alvaro Christopher G, Thorner Jeremy
From the Division of Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202.
From the Division of Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202
J Biol Chem. 2016 Apr 8;291(15):7788-95. doi: 10.1074/jbc.R116.714980. Epub 2016 Feb 23.
The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeastSaccharomyces cerevisiaewere isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview.
1985年，编码对出芽酵母酿酒酵母的肽类交配信息素作出反应的受体的DNA被分离出来，它们是在任何生物体中克隆的首批激动剂结合型异源三聚体G蛋白偶联受体（GPCR）基因。如今，30多年过去了，正如这篇回顾性综述中所描述的，这种酵母及其受体继续为研究GPCR引发的信号传导及其调控提供一种开拓性的实验范式。
