The Ohio State University, Columbus, OH, USA.
J Endod. 2011 May;37(5):593-7. doi: 10.1016/j.joen.2011.02.015. Epub 2011 Mar 22.
The purpose of this prospective, randomized, double-blind, placebo-controlled study was to determine the effect of the administration of the combination of preoperative ibuprofen/acetaminophen on the success of the inferior alveolar nerve (IAN) block in patients with symptomatic irreversible pulpitis.
One hundred endodontic emergency patients in moderate to severe pain diagnosed with irreversible pulpitis of a mandibular posterior tooth randomly received, in a double-blind manner, identical capsules of either a combination of 800 mg ibuprofen and 1000 mg acetaminophen or placebo 45 minutes before the administration of a conventional IAN block. Access was begun 15 minutes after completion of the IAN block, and all patients had profound lip numbness. Success was defined as no or mild pain (visual analog scale recordings) on access or initial instrumentation.
The success rate for the IAN block was 32% for the combination ibuprofen/acetaminophen group and 24% for the placebo, with no significant difference (P = .37) between the 2 groups. For mandibular posterior teeth, a combination dose of 800 mg ibuprofen and 1000 mg acetaminophen given 45 minutes before administration of the IAN block did not result in a statistically significant increase in anesthetic success in patients with symptomatic irreversible pulpitis.
本前瞻性、随机、双盲、安慰剂对照研究的目的是确定术前给予布洛芬/对乙酰氨基酚联合用药对有症状不可复性牙髓炎患者下齿槽神经（IAN）阻滞成功率的影响。
100 名患有下颌后牙不可复性牙髓炎且处于中重度疼痛的牙髓病急诊患者，以双盲方式随机接受 800mg 布洛芬和 1000mg 对乙酰氨基酚联合用药或安慰剂胶囊，在常规 IAN 阻滞前 45 分钟给药。在 IAN 阻滞完成后 15 分钟开始进入，所有患者均有明显的嘴唇麻木。成功定义为进入或初始器械操作时无或轻度疼痛（视觉模拟评分记录）。
联合布洛芬/对乙酰氨基酚组 IAN 阻滞的成功率为 32%，安慰剂组为 24%，两组间无显著差异（P=.37）。对于下颌后牙，在 IAN 阻滞前 45 分钟给予 800mg 布洛芬和 1000mg 对乙酰氨基酚的联合剂量并未显著增加有症状不可复性牙髓炎患者的麻醉成功率。
