J Endod. 2010 Mar;36(3):379-82. doi: 10.1016/j.joen.2009.12.030.
The purpose of this prospective, randomized, double-blind, placebo-controlled study was to determine the effect of the administration of preoperative ibuprofen on the success of the inferior alveolar nerve block (IAN) in patients with irreversible pulpitis.
One hundred endodontic emergency patients diagnosed with irreversible pulpitis of a mandibular posterior tooth randomly received, in a double-blind manner, identical capsules of either 800 mg ibuprofen or placebo 45 minutes before the administration of a conventional IAN block. Access was begun 15 minutes after completion of the IAN block, and all patients had profound lip numbness. Success was defined as no or mild pain (visual analogue scale recordings) on access or initial instrumentation.
The success rate for the IAN block was 41% with ibuprofen and 35% with placebo, with no significant difference (P=.57) between the 2 groups. For mandibular posterior teeth, a dose of 800 mg of ibuprofen given 45 minutes before the administration of the IAN block did not result in a statistically significant increase in anesthetic success in patients with irreversible pulpitis.
本前瞻性、随机、双盲、安慰剂对照研究的目的是确定术前给予布洛芬对不可逆性牙髓炎患者下颌神经阻滞（IAN）成功率的影响。
100 名诊断为下颌后牙不可逆性牙髓炎的牙髓急症患者以双盲方式随机接受 800mg 布洛芬或安慰剂胶囊，在常规 IAN 阻滞前 45 分钟给予。在 IAN 阻滞完成后 15 分钟开始进行牙体预备，所有患者均出现明显的唇麻木。成功定义为在牙体预备或初次器械操作时无疼痛或轻度疼痛（视觉模拟评分记录）。
布洛芬组 IAN 阻滞成功率为 41%，安慰剂组为 35%，两组间无显著差异（P=.57）。对于下颌后牙，在 IAN 阻滞前 45 分钟给予 800mg 布洛芬剂量并未使不可逆性牙髓炎患者的麻醉成功率有统计学显著增加。
