非急性炎症综合征中血浆蛋白S系统成分定量修饰的研究。

Study of quantitative modifications of the plasma protein S system components in non-acute inflammatory syndromes.

作者信息

Schved J F, Gris J C, Sarlat C, Amiral J, Brun S, Brunschwig C, Petris I, Lassonery M

机构信息

Laboratoire d'Hématologie et Immunologie, Centre Hospitalier Régional et Universitaire de Nîmes, France.

出版信息

Nouv Rev Fr Hematol (1978). 1990;32(4):271-6.

PMID:2149752

Abstract

Thrombosis frequently accompanies inflammatory disease. There are numerous and frequent modifications of haemostasis parameters during inflammatory disease. Deficiencies in protein S, a protein C cofactor, are predisposing factors for thromboses. In 43 patients with biological inflammatory syndromes (ESR above 80 mm in the first hour found twice in a three-day period and disturbances of other biological inflammatory markers) we studied the variations of the protein S system: total antigenic protein S, free antigenic protein S, C4b BP, all antigenic fractions being assayed by electro-immuno diffusion. The results show an increase in free protein S (mean 114.3%, range 25%-180%, P less than 0.005), the biologically active fraction of protein S. They also evidence the expected increase in C4b BP (mean 188.3%, range 41%-335%, P less than 10(-5]. There is an increase in total protein S Ag (mean 145.3%, range 56%-220%, P less than 10(-5]. The results show a high positive correlation between the increased free protein S Ag and total protein S Ag (r' = 0.78, P less than 0.01), between total protein S and C4b BP (r' = 0.8, P less than 0.01) and between free protein S and C4b BP (r' = 0.73, P less than 0.01). C4b BP concentrations are correlated with haptoglobin (r' = 0.59, P less than 0.01), orosomucoid (r' = 0.53, P less than 0.01), C3 complement component (r' = 0.80, P less than 0.01), C4 (r' = 0.39, P less than 0.02) and platelet count (r' = 0.51, P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

血栓形成常伴随炎症性疾病。在炎症性疾病期间，止血参数有许多频繁的改变。蛋白S（一种蛋白C辅因子）缺乏是血栓形成的易感因素。在43例患有生物炎症综合征的患者中（在三天内两次发现第一小时血沉超过80mm以及其他生物炎症标志物紊乱），我们研究了蛋白S系统的变化：总抗原性蛋白S、游离抗原性蛋白S、C4b结合蛋白（C4b BP），所有抗原组分均通过电免疫扩散法测定。结果显示游离蛋白S增加（平均114.3%，范围25% - 180%，P < 0.005），即蛋白S的生物活性组分增加。结果还证实C4b BP预期增加（平均188.3%，范围41% - 335%，P < 10⁻⁵）。总蛋白S抗原（Ag）增加（平均145.3%，范围56% - 220%，P < 10⁻⁵）。结果显示游离蛋白S Ag增加与总蛋白S Ag之间呈高度正相关（r' = 0.78，P < 0.01），总蛋白S与C4b BP之间呈高度正相关（r' = 0.8，P < 0.01），游离蛋白S与C4b BP之间呈高度正相关（r' = 0.73，P < 0.01）。C4b BP浓度与触珠蛋白（r' = 0.59，P < 0.01）、orosomucoid（r' = 0.53，P < 0.01）、C3补体成分（r' = 0.80，P < 0.01）、C4（r' = 0.39，P < 0.02）和血小板计数（r' = 0.51，P < 0.01）相关。（摘要截断于250字）