Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
J Thorac Cardiovasc Surg. 2011 Sep;142(3):650-5. doi: 10.1016/j.jtcvs.2011.02.038. Epub 2011 Apr 17.
The impact of Society of Thoracic Surgeons predicted mortality risk score on resource use has not been previously studied. We hypothesize that increasing Society of Thoracic Surgeons risk scores in patients undergoing aortic valve replacement are associated with greater hospital charges.
Clinical and financial data for patients undergoing aortic valve replacement at The Johns Hopkins Hospital over a 10-year period (January 2000 to December 2009) were reviewed. The current Society of Thoracic Surgeons formula (v2.61) for in-hospital mortality was used for all patients. After stratification into risk quartiles, index admission hospital charges were compared across risk strata with rank-sum and Kruskal-Wallis tests. Linear regression and Spearman's coefficient assessed correlation and goodness of fit. Multivariable analysis assessed relative contributions of individual variables on overall charges.
A total of 553 patients underwent aortic valve replacement during the study period. Average predicted mortality was 2.9% (±3.4) and actual mortality was 3.4% for aortic valve replacement. Median charges were greater in the upper quartile of patients undergoing aortic valve replacement (quartiles 1-3, $39,949 [interquartile range, 32,708-51,323] vs quartile 4, $62,301 [interquartile range, 45,952-97,103], P < .01]. On univariate linear regression, there was a positive correlation between Society of Thoracic Surgeons risk score and log-transformed charges (coefficient, 0.06; 95% confidence interval, 0.05-0.07; P < .01). Spearman's correlation R-value was 0.51. This positive correlation persisted in risk-adjusted multivariable linear regression. Each 1% increase in Society of Thoracic Surgeons risk score was associated with an added $3000 in hospital charges.
This is the first study to show that increasing Society of Thoracic Surgeons risk score predicts greater charges after aortic valve replacement. As competing therapies, such as percutaneous valve replacement, emerge to treat high-risk patients, these results serve as a benchmark to compare resource use.
胸外科医师协会预测死亡率评分对资源利用的影响尚未得到研究。我们假设,主动脉瓣置换术患者的胸外科医师协会风险评分增加与医院费用增加相关。
回顾了约翰霍普金斯医院 10 年期间(2000 年 1 月至 2009 年 12 月)接受主动脉瓣置换术患者的临床和财务数据。所有患者均使用当前胸外科医师协会(第 2.61 版)公式计算院内死亡率。分层为风险四分位后,使用秩和检验和 Kruskal-Wallis 检验比较风险分层内的指数入院医院费用。线性回归和 Spearman 系数评估相关性和拟合优度。多变量分析评估各个变量对总费用的相对贡献。
在研究期间,共有 553 名患者接受了主动脉瓣置换术。平均预测死亡率为 2.9%(±3.4),实际死亡率为 3.4%。主动脉瓣置换术患者的中位数费用在四分位较高的患者中较高(四分位 1-3,$39,949[四分位距,32,708-51,323]vs四分位 4,$62,301[四分位距,45,952-97,103],P<.01)。在单变量线性回归中,胸外科医师协会风险评分与对数转换后的费用之间存在正相关(系数,0.06;95%置信区间,0.05-0.07;P<.01)。Spearman 相关 R 值为 0.51。这种正相关在风险调整后的多变量线性回归中仍然存在。胸外科医师协会风险评分每增加 1%,医院费用增加 3000 美元。
这是第一项表明胸外科医师协会风险评分增加预测主动脉瓣置换术后费用增加的研究。随着经皮瓣膜置换术等竞争疗法的出现来治疗高危患者,这些结果为比较资源利用提供了基准。