Centre National de la Recherche Scientifique Unité Mixte de Recherche 6247 and Institut National de la Santé et de la Recherche Médicale Unité 931 - Genetics, Reproduction and Development, Clermont University, 24 avenue des Landais, 63177 Aubière CEDEX, France.
Trends Genet. 2011 May;27(5):177-85. doi: 10.1016/j.tig.2011.02.002. Epub 2011 Apr 15.
Heterochromatin at pericentric satellites, characterized by a specific chromatin signature and chromocenter organization, is of paramount importance for genome function. Re-establishment of this organization after fertilization takes place in the context of genome-wide epigenetic reprogramming. We review how the asymmetry in histone variants and post-translational modifications between paternal and maternal genomes and their respective pericentric heterochromatin domains evolve during early cleavage stages in mouse. We draw a parallel between these data and the burst of pericentric satellite transcription that occurs concomitantly with the dynamic reorganization of the pericentric domains into chromocenters in two-cell stage embryos. Based on this new angle, we propose that a crucial developmental transition at the two-cell stage allows chromocenter formation by involving non-coding satellite transcripts to trigger specific chromatin changes.
着丝粒卫星处的异染色质，具有特定的染色质特征和着丝粒中心组织，对基因组功能至关重要。这种组织在受精后的基因组广泛的表观遗传重编程过程中重新建立。我们回顾了在小鼠早期卵裂阶段，父本和母本基因组及其各自着丝粒异染色质域之间组蛋白变体和翻译后修饰的不对称性是如何演变的。我们将这些数据与同时发生的着丝粒卫星转录的爆发进行了比较，在两细胞期胚胎中，着丝粒域动态重组成着丝粒中心。基于这个新角度，我们提出在两细胞阶段的一个关键发育转变，通过涉及非编码卫星转录本来触发特定的染色质变化，从而允许形成着丝粒中心。
