Medek A, Komenda S
Research Institute of Higher Nervous Activity, Palacký University, Olomouc, Czechoslovakia.
Acta Univ Palacki Olomuc Fac Med. 1990;128:57-63.
Reproduction of fixed conditioned alimentary motor reflexes in long-time laboratory kept cats in the course of the year is remarkably influenced by the sexual cycle. Estrus, anestrus, gestation and deliveries act upon the reflex reproduction in a similar way like deliberate application of experimental stress of various intensity. The study of the antistress efficacy of drugs modifying psychological functions and mental states in the method of reproduction of fixed alimentary motor reflexes under stress must specify the actual effect of experimental stress. Experimental sensory stress represented by intermittent sound of 98 dB and intermittent light (0.6 joules) acting with simultaneous frequency of 6 Hz was found to generally impair reflex reproduction over the whole period of twelve months. Correct response latencies were significantly prolonged and incorrect motor reactions significantly increased. If reflex reproduction was impaired due to the sexual cycle, simultaneous sensory stress still aggravates the impairment. The definition of the actual efficacy of experimental stressing thus necessarily requires regular control experiments in the course of the year with reproduction influenced neither by stress nor drugs at least at forthightly intervals.
在一年的时间里，长期饲养在实验室中的猫的固定条件性食物运动反射的重现会受到性周期的显著影响。发情期、乏情期、妊娠期和分娩对反射重现的作用，类似于有意施加各种强度的实验应激。在应激状态下通过固定食物运动反射重现的方法来研究调节心理功能和精神状态的药物的抗应激效果时，必须明确实验应激的实际影响。以98分贝的间歇性声音和频率为6赫兹的0.6焦耳间歇性光同时作用所代表的实验性感觉应激，发现在整个十二个月期间通常会损害反射重现。正确反应潜伏期显著延长，错误运动反应显著增加。如果反射重现因性周期而受损，同时存在的感觉应激仍会加重这种损害。因此，要确定实验应激的实际效果，必然需要在一年中定期进行对照实验，至少每两周进行一次，使反射重现不受应激或药物的影响。
