慢性甲基苯丙胺治疗对大鼠脑中选择性D1-多巴胺受体配体[3H]SCH 23390结合参数的影响。

Effects of chronic methamphetamine treatment on the binding parameters of [3H]SCH 23390, a selective D1-dopamine receptor ligand, in the rat brain.

作者信息

Nonaka R, Moroji T

机构信息

Department of Psychopharmacology, Psychiatric Research Institute of Tokyo, Japan.

出版信息

Neurosci Lett. 1990 Nov 27;120(1):109-12. doi: 10.1016/0304-3940(90)90180-h.

DOI:10.1016/0304-3940(90)90180-h

PMID:2149876

Abstract

Following the determination of the binding characteristics of [3H]SCH 23390 using slide-mounted tissue sections of molded minced forebrain, the effects of chronic methamphetamine (MAP) treatment (at a dose of 4 mg/kg for 14 days) on D1 receptors in the rat brain were studied using quantitative receptor autoradiography. There were no differences in both Kd(app) and Bmax values between vehicle- and MAP-treated rats, indicating that D1 receptors might not be involved in the development of behavioral sensitization in chronically MAP-treated rats.

摘要

在用模制切碎的前脑组织的载玻片组织切片确定[3H]SCH 23390的结合特性之后，使用定量受体放射自显影术研究了慢性甲基苯丙胺（MAP）治疗（剂量为4mg/kg，持续14天）对大鼠脑中D1受体的影响。在给予赋形剂和MAP处理的大鼠之间，Kd（app）和Bmax值均无差异，表明D1受体可能不参与慢性MAP处理大鼠行为敏化的发展。