Kuroda Hiroyuki, Sakurai Tamaki, Yamada Michiko, Uemura Naoki, Ono Michihiro, Abe Tomoyuki, Fujii Shigeyuki, Maeda Masahiro, Kohda Kyuhei, Obata Masahiko, Ando Masakatsu, Iyama Satoshi, Kato Junji
Dept. of Gastroenterology, Shinnittetsu Muroran General Hospital, Japan.
Gan To Kagaku Ryoho. 2011 Apr;38(4):627-30.
Salivary ductcarcinoma (SDC)is a high-grade malignant tumor arising predominantly in the parotid gland. Androgen receptor(AR)expression was mainly restricted to SDC in salivary cancer. We report successful treatment of a patient with advanced SDC using an endocrine chemotherapy. A 76-year-old man was hospitalized with lumbalgia and swelling of left submandibular region. Radiological examination indicated a tumor in left submandibular gland and metastatic tumors in lumbar vertebra, accompanied by swollen lymph nodes of the neck, mediastinum. Needle biopsies of both vertebral tumor and cervical lymph node revealed SDC. Positive nuclear staining was observed against AR in tumor cells of our patient by immunohistochemical analysis. He obtained a partial response after 1 course of treatment with both anti-androgen therapy and palliative chemotherapy using paclitaxel. In contrast to previous reports of poor response to chemotherapy alone and short-term survival of patients with SDC, our patient has demonstrated that chemotherapy combined with anti-androgen therapy may be an effective modality as a therapeutic regimen for SDC.
涎腺导管癌（SDC）是一种主要发生于腮腺的高级别恶性肿瘤。雄激素受体（AR）表达主要局限于涎腺癌中的SDC。我们报告了1例采用内分泌化疗成功治疗晚期SDC患者的病例。1名76岁男性因腰痛和左下颌下区肿胀入院。影像学检查显示左下颌下腺有肿瘤，腰椎有转移瘤，伴有颈部、纵隔淋巴结肿大。椎体肿瘤和颈部淋巴结穿刺活检均显示为SDC。免疫组化分析显示，我们的患者肿瘤细胞中AR呈阳性核染色。在接受1个疗程的抗雄激素治疗联合使用紫杉醇的姑息化疗后，他获得了部分缓解。与之前关于SDC患者单独化疗反应不佳和短期生存的报道不同，我们的患者表明化疗联合抗雄激素治疗可能是一种有效的SDC治疗方案。
