The Motherisk Program, Division of Clinical Pharmacology and Toxicology, University of Toronto, Toronto, Canada.
J Cardiovasc Pharmacol. 2011 Jul;58(1):20-4. doi: 10.1097/FJC.0b013e31821c471b.
Being the most common group of congenital malformations, congenital heart defects have often been investigated to rule out teratogenic effects by medicinal drugs and chemicals. Yet, the use of rigorous epidemiological methods has rejected such claims in many cases. We critically evaluate drugs believed to be associated with an increased risk of causing congenital heart defects, highlighting the debate and the practical implications of such associations.
先天性心脏缺陷是最常见的先天性畸形之一，人们经常研究它们，以排除药物和化学物质的致畸作用。然而，在许多情况下，严格的流行病学方法已经否定了这些说法。我们批判性地评估了那些被认为与增加先天性心脏缺陷风险相关的药物，强调了这种关联的争议和实际意义。
