Larocca L M, Lauriola L, Ranelletti F O, Piantelli M, Maggiano N, Ricci R, Capelli A
Istituti di Anatomia Patologica e di Istologia, Università Cattolica del S. Cuore, Rome, Italy.
Am J Med Genet Suppl. 1990;7:225-30. doi: 10.1002/ajmg.1320370745.
The incidence and severity of various histologic changes were studied in the thymuses from 35 Down syndrome (DS) patients. Variable histologic alterations up to fibrotic involution of the gland were found. In addition, immunohistochemical investigation showed a reduction or absence of interdigitating reticulum cells roughly correlated with the severity of morphologic changes. The complex architectural and cellular thymic alterations, concerning both cortical and medullary microenvironment, could be correlated with the imbalances of immunity in DS patients.
对35例唐氏综合征（DS）患者的胸腺进行研究，观察各种组织学变化的发生率和严重程度。发现存在不同程度的组织学改变，直至腺体发生纤维化萎缩。此外，免疫组化研究显示，交错突网状细胞数量减少或缺失，这大致与形态学变化的严重程度相关。涉及皮质和髓质微环境的复杂胸腺结构和细胞改变，可能与DS患者的免疫失衡有关。
