金催化合成氨基酸衍生的 2,5-二取代恶唑。
Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles.
机构信息
Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323, Harry Hines Blvd., Dallas, Texas 75390, USA.
出版信息
Org Biomol Chem. 2011 Jun 7;9(11):4017-20. doi: 10.1039/c1ob05390f. Epub 2011 Apr 18.
PMID:21499644
Abstract
Amino acid-derived propargylic amides are cyclised in a one-pot, Au(III)-catalysed operation to yield 5-bromomethyl oxazoles. These compounds are further elaborated to bis-heterocycles, dipeptide mimics and more.
摘要
氨基酸衍生的炔丙酰胺在一锅、金（III）催化的操作中环化，生成 5-溴甲基恶唑。这些化合物进一步被修饰为双杂环、二肽类似物等。
Zotero 插件