兔和大鼠输卵管不同区域肾上腺素能反应性的研究。

Studies of the adrenergic reactivity in different regions of rabbit and rat oviduct.

作者信息

Chernaeva L, Milenov K

出版信息

Acta Physiol Pharmacol Bulg. 1978;4(1):19-25.

Abstract

Experiments are made to study the spontaneous contractions and the contractile response to noradrenaline of muscle strips isolated in longitudinal direction from the ampulla, isthmus and horn of the oviduct. Left oviduct of rats (in oestrus and dioestrus) and rabbits (in dioestrus) was used. In both rats and rabbits, all muscle strips including the ovarium manifest spontaneous contractions with highest frequency in the ovarium and ampulla, lower in the isthmus and lowest in the horn. Noradrenaline inhibits spontaneous contractions of strips in rat oviduct and ovarium. The inhibitory effect is manifested at lower noradrenaline concentration for the horn and isthmus (maximum effective concentration 3 X 10(-7) M in dioestrus and 3 X 10(-6) M in oestrus) compared with the ampulla and the ovarium (3 X 10(-6) M in dioestrus and 3 x 10(-5) in oestrus). Noradrenaline stimulates rabbit oviduct contractions . The stimulating response is manifested at lower noradrenaline concentration (1 X 10(-8) M minimum effective concentration) for the isthmus, higher for the horn (5 X 10(-7) M) and highest for the ampulla (5 X 10(-6) M). The presence of different alpha- and beta-adrenergic reactivities in the different areas of the oviduct is discussed.

摘要

进行实验以研究从输卵管壶腹部、峡部和角部纵向分离的肌肉条的自发收缩以及对去甲肾上腺素的收缩反应。使用大鼠（发情期和间情期）和兔子（间情期）的左侧输卵管。在大鼠和兔子中，所有包括卵巢在内的肌肉条均表现出自发收缩，卵巢和壶腹部的频率最高，峡部较低，角部最低。去甲肾上腺素抑制大鼠输卵管和卵巢中肌肉条的自发收缩。与壶腹部和卵巢相比，去甲肾上腺素对角部和峡部的抑制作用在较低浓度时就表现出来（间情期最大有效浓度为3×10⁻⁷ M，发情期为3×10⁻⁶ M，而壶腹部和卵巢在间情期为3×10⁻⁶ M，发情期为3×10⁻⁵ M）。去甲肾上腺素刺激兔子输卵管收缩。刺激反应在峡部较低浓度（最低有效浓度1×10⁻⁸ M）时表现出来，角部较高（5×10⁻⁷ M），壶腹部最高（5×10⁻⁶ M）。文中讨论了输卵管不同区域存在不同的α和β肾上腺素能反应性。