Hossack K F, Adair O V, Crowley S T
Department of Medicine, University of Colorado, Health Sciences Center, Denver.
Cardiology. 1990;77(6):433-42. doi: 10.1159/000174635.
In an attempt to determine factors that are related to atrial natriuretic factor (ANF) release in normal subjects, 10 male volunteers were studied at rest supine, sitting and during treadmill exercise. Echocardiography was used to measure atrial volumes, and a Swan-Ganz catheter was used to measure right atrial pressure and pulmonary artery wedge pressure. Right ventricular ANF increased from 33 +/- 22 pg/ml supine to 72 +/- 32 pg/ml at peak exercise (p less than 0.001). When heart rate, atrial volume and atrial phasic pressure were combined to calculate atrial minute circumferential wall stress, a significant relationship between left and right atrial values for this variable and ANF was present. An association between norepinephrine (NE) and ANF was also present, but in a multivariate analysis it was not significant. This probably does not represent cause and effect but rather an association due to the relationship between NE and heart rate.
为了确定与正常受试者心房利钠因子（ANF）释放相关的因素，对10名男性志愿者在静息仰卧位、坐位及跑步机运动期间进行了研究。使用超声心动图测量心房容积，并用Swan-Ganz导管测量右心房压力和肺动脉楔压。右心室ANF从仰卧位时的33±22 pg/ml增加到运动峰值时的72±32 pg/ml（p<0.001）。当将心率、心房容积和心房相压力结合起来计算心房每分钟圆周壁应力时，该变量的左右心房值与ANF之间存在显著关系。去甲肾上腺素（NE）与ANF之间也存在关联，但在多变量分析中并不显著。这可能并不代表因果关系，而更可能是由于NE与心率之间的关系而产生的一种关联。
