[Protective effect of fospropofol disodium on in vivo liver ischemia-reperfusion injury in rats].

OBJECTIVE

To investigate the protective effect and mechanisms of Fospropofol disodium on in vivo liver ischemia-reperfusion injury in rats.

METHODS

Forty SD rats were randomly divided into 5 groups: sham operation group, NS pretreated group (NS), Fospropofol disodium pretreated group (SP), Propofol pretreated group (P) and 10% fat milk pretreated group (Z). After the hepatic inflow was occluded for 30 min and reperfused for 90 min, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were determined, and the liver specimen were obtained for the determination of superoxide dismutase (SOD) activities and malondialdehyde (MDA) contents and for microscopic examinations.

RESULTS

The serum levels of ALT, AST and LDH in the rats in group NS, SP, P, and Z after liver ischemia-reperfusion were significantly higher than those with sham operations (P < 0.01). The serum levels of ALT, AST and LDH in the rats in group SP, P, Z were significantly lower than those in group NS (P < 0.01). The MDA contents and SOD activities in the livers of rats in group NS, SP, P and Z were significantly higher than in those with sham operations (P < 0.01). The MDA contents and SOD activities in the livers of rats in group SP, P and Z were significantly lower than those in group NS (P < 0.01).

CONCLUSION

Fospropofol Disodium has a protective effect on rat livers against ischemia-reperfusion injury, which is related with antioxidation.