INSERM UMRS_938, CdR Saint-Antoine, Paris, France.
Clin Res Hepatol Gastroenterol. 2011 Mar;35(3):176-81. doi: 10.1016/j.clinre.2010.11.009. Epub 2011 Jan 28.
Scaffold proteins are defined by the presence of specific protein-binding domains (e.g. PDZ domains) that assemble several proteins into functional complexes. Thus, scaffolds are critical for spatio-temporal organization and for proper regulation of intracellular signalling upon specific stimulus. Identified 15years ago, NHERF scaffold proteins contain several PDZ modules and were initially viewed as "passive linkers" between transmembrane proteins and the cortical cytoskeleton underlying the plasma membrane. New NHERF-binding molecules involved in cell signalling have been recently identified. Thus, NHERFs are now viewed as "active" key players in regulating cellular functions. EBP50 and PDZK1, two members of the NHERF family, are highly expressed in the liver where they link receptors, channels, transporters and cytosolic components. This review aims to give an overview of the emerging functions of NHERF proteins in liver physiology.
支架蛋白的定义是其存在特定的蛋白结合域（例如 PDZ 结构域），这些结构域将几种蛋白组装成功能复合物。因此，支架蛋白对于特定刺激时的细胞内信号时空组织和适当调节至关重要。15 年前发现的 NHERF 支架蛋白含有几个 PDZ 模块，最初被视为跨膜蛋白和位于质膜下的皮质细胞骨架之间的“被动接头”。最近发现了参与细胞信号转导的新的 NHERF 结合分子。因此，NHERF 现在被视为调节细胞功能的“活跃”关键因子。NHERF 家族的两个成员 EBP50 和 PDZK1 在肝脏中高表达，它们将受体、通道、转运体和细胞质成分连接起来。这篇综述旨在概述 NHERF 蛋白在肝脏生理学中的新兴功能。
