Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Av. Universitaria 1440, Goiania, Goias, Brazil.
Braz J Infect Dis. 2011 Mar-Apr;15(2):151-5.
Highly active antiretroviral therapy (HAART) reduces AIDS-related morbidity and mortality, however it has been associated with metabolic abnormalities. This study estimated the prevalence of lipid abnormalities and related factors among patients on HAART. A cross-sectional study was conducted on adult patients, in central Brazil. Patients were interviewed, and blood obtained for lipids measurement. Dyslipidemia was defined as total cholesterol (TC) > 240 mg/dL, low-density lipoprotein (LDL) > 160 mg/dL, triglycerides (TG) > 200 and/or high-density lipoprotein (HDL) < 40 mg/dL. Multiple logistic regression analyses were performed (SPSS 13.0). One hundred and thirteen patients were recruited. Mean age was 39.3 years; 68.1% were males; 50.4% were on nucleoside reverse transcriptase inhibitors (NRTI) in combination with non-nucleoside reverse transcriptase inhibitors (NNRTI), while 42.5% were on NRTI in combination with protease inhibitors (PIs). The prevalence of dyslipidemia was 66.7%. Low HDL was the most frequent abnormality (53.5%), followed by high TG (36.1%). Patients on a PI regimen had a 5.2-fold higher risk (95% CI: 1.8-14.8) of dyslipidemia, even after adjusting for sex, age, and duration of HIV infection/AIDS. The study discloses a high prevalence rate of dyslipidemia and points out a need for intervention programs to reduce future cardiovascular events in patients, on HAART.
高效抗逆转录病毒疗法（HAART）降低了艾滋病相关发病率和死亡率，但它与代谢异常有关。本研究旨在评估接受 HAART 的患者中血脂异常的流行情况及其相关因素。在巴西中部进行了一项横断面研究，纳入了成年患者。对患者进行访谈并采集血液以测量血脂。血脂异常定义为总胆固醇（TC）>240mg/dL、低密度脂蛋白（LDL）>160mg/dL、三酰甘油（TG）>200mg/dL 和/或高密度脂蛋白（HDL）<40mg/dL。采用多因素逻辑回归分析（SPSS 13.0）。共纳入 113 例患者，平均年龄为 39.3 岁，68.1%为男性，50.4%的患者接受核苷类逆转录酶抑制剂（NRTI）联合非核苷类逆转录酶抑制剂（NNRTI）治疗，42.5%的患者接受 NRTI 联合蛋白酶抑制剂（PI）治疗。血脂异常的患病率为 66.7%。低 HDL 血症最为常见（53.5%），其次是高 TG（36.1%）。与接受 NRTI 联合 NNRTI 治疗的患者相比，接受 PI 方案治疗的患者发生血脂异常的风险增加了 5.2 倍（95%CI：1.8-14.8），即使在校正了性别、年龄和 HIV 感染/艾滋病持续时间等因素后。该研究揭示了血脂异常的高患病率，并指出需要实施干预计划以降低接受 HAART 治疗的患者未来发生心血管事件的风险。
